Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation

Aging Cell
Sébastien P Gendron, Patrick J Rochette

Abstract

With age, structural and functional changes can be observed in human cornea. Some studies have shown a loss of corneal transparency and an increase in turbidity associated with aging. These changes are caused by modifications in the composition and arrangement of extracellular matrix in the corneal stroma. In human skin, it is well documented that exposure to solar radiation, and mainly to the UVA wavelengths, leads to phenotypes of photoaging characterized by alteration in extracellular matrix of the dermis. Although the cornea is also exposed to solar radiation, the extracellular matrix modifications observed in aging corneas have been mainly attributed to chronological aging and not to solar exposure. To ascertain the real implication of UVA exposure in extracellular matrix changes observed with age in human cornea, we have developed a model of photoaging by chronically exposing corneal stroma keratocytes with a precise UVA irradiation protocol. Using this model, we have analyzed UVA-induced transcriptomic and proteomic changes in corneal stroma. Our results show that cumulative UVA exposure causes changes in extracellular matrix that are found in corneal stromas of aged individuals, suggesting that solar exposure catalyzes ...Continue Reading

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Citations

Sep 14, 2016·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Saeed AkhtarTurki M Almubrad
Mar 17, 2017·PloS One·Marie-Catherine Drigeard DesgarnierPatrick J Rochette
May 14, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Sandra Freitas-RodríguezCarlos López-Otín

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