Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36.

Blood
Benoit GamainDror I Baruch

Abstract

Adhesion of mature Plasmodium falciparum parasitized erythrocytes to microvascular endothelial cells or to placenta contributes directly to the virulence and severe pathology of P falciparum malaria. Whereas CD36 is the major endothelial receptor for microvasculature sequestration, infected erythrocytes adhering in the placenta bind chondroitin sulfate A (CSA) but not CD36. Binding to both receptors is mediated by different members of the large and diverse protein family P falciparum erythrocyte membrane protein-1 (PfEMP-1) and involves different regions of the molecule. The PfEMP-1-binding domain for CD36 resides in the cysteine-rich interdomain region 1 (CIDR-1). To explore why CSA-binding parasites do not bind CD36, CIDR-1 domains from CD36- or CSA-binding parasites were expressed in mammalian cells and tested for adhesion. Although CIDR-1 domains from CD36-adherent strains strongly bound CD36, those from CSA-adherent parasites did not. The CIDR-1 domain has also been reported to bind CSA. However, none of the CIDR-1 domains tested bound CSA. Chimeric proteins between CIDR-1 domains that bind or do not bind CD36 and mutagenesis experiments revealed that modifications in the minimal CD36-binding region (M2 region) are respons...Continue Reading

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C F OckenhouseG A Jamieson
Jun 1, 1991·Parasitology·W RuangjirachupornP Perlmann
Mar 1, 1991·Infection and Immunity·M HoN J White
Nov 1, 1989·Experimental Parasitology·J W Barnwell
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P H DavidL D Oligino
Jul 1, 1995·The Journal of Experimental Medicine·S J RogersonG V Brown
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·D I BaruchB L Pasloske
Nov 5, 1997·The American Journal of Tropical Medicine and Hygiene·C NewboldK Marsh
Apr 16, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Fried, P E Duffy
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·R E HaywardK P Day
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·J C ReederG V Brown
Sep 25, 1999·The American Journal of Tropical Medicine and Hygiene·S J RogersonM E Molyneux
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·P A BuffetA Scherf
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J D SmithL H Miller
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·K R TrenholmeD J Kemp
Jul 15, 2000·Baillière's Best Practice & Research. Clinical Haematology·D I Baruch
Nov 9, 2000·Molecular and Biochemical Parasitology·J D SmithL H Miller

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Citations

Sep 18, 2007·Parasitology Research·Kanjaksha Ghosh, Kinjalka Ghosh
Nov 19, 2002·International Journal for Parasitology·Andreas Heddini
Mar 19, 2002·Molecular and Biochemical Parasitology·Louis H MillerAllan J Saul
Mar 2, 2002·Trends in Parasitology·J D SmithS Kyes
Sep 24, 2010·PLoS Computational Biology·Thomas S RaskThomas Lavstsen
Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sylvie GratepancheLouis H Miller
Jul 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Benoit GamainDror I Baruch
Jan 17, 2007·International Journal for Parasitology·Benoît GamainArtur Scherf
Sep 27, 2016·Nature Communications·Fu-Lien HsiehMatthew K Higgins
Feb 8, 2002·Nature·Louis H MillerOgobara K Doumbo
Nov 26, 2002·Hematology·David J WeatherallDavid J Roberts

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