PMID: 3748779Aug 1, 1986Paper

Modifications in the histochemical and biochemical changes in tenotomized rat soleus by denervation

Pflügers Archiv : European journal of physiology
C L Talesara, P K Jasra

Abstract

Response of tenotomized rat soleus muscle to denervation performed at different time intervals, has been investigated. Tenotomized muscles showed typical central core lesions seven days post-operatively. These were not observed in m-ATPase stained sections of simultaneously denervated and tenotomized muscles, and muscles denervated 24 h after tenotomy. Central core lesions were not prevented in muscles denervated 28 h after tenotomy, indicating that tenotomy effects responsible for central lesions are completed by this time. Myosin light chain pattern of muscles denervated 28 h after tenotomy, and tenotomized only were similar showing increased LC3/LC1 ratio. Simultaneously denervated and tenotomized muscle however showed all the three light chains relatively equal in quantity. The results suggest that elimination of neural activation within 28 h prevents myofibrillar loss and minimized other changes which occur due to tenotomy.

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Citations

Jul 5, 2001·Archives of Histology and Cytology·E A Abou SalemY Komiya
Nov 20, 2008·Muscle & Nerve·David V BaewerDanny A Riley
Feb 16, 2012·Muscle & Nerve·Jonathan M Van DykeDanny A Riley
Sep 1, 1990·The Anatomical Record·B R Pachter, N I Spielholz

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