PMID: 1851487Apr 1, 1991Paper

Modifications induced by gestational hypertension on platelet calcium transport

Experimental and Molecular Pathology
C RomaniniL Mazzanti


Several studies have recently demonstrated that the platelets of subjects affected by essential hypertension have, in their basal state, an elevated cellular calcium content. Such data appear particularly interesting with regard to gestational hypertension (GH). Supposing that the intracellular calcium may be involved in the regulation of blood pressure we have studied the cytosolic calcium concentration, Na+/K(+)-ATPase activity, Ca(2+)-ATPase activity, fluidity, and the cholesterol/phospholipid (C/P) molar ratio of the plasma membranes in platelets from 20 normotensive pregnant women and 20 women affected by mild gestational hypertension without pharmacological treatment, near term. We observed an increased Ca(2+)-ATPase activity and a decreased Na(+)K(+)-ATPase activity in GH compared to the controls, accompanied by an increased Ca2+ intraplatelet concentration in the same patients. The fluidity and the C/P molar ratio were also increased. Our study gives indirect support to the hypothesis, supposing a reduced Na+/K(+)-ATPase activity which might cause increased intracellular Na+ content and decreased Ca2+ efflux through the Na+/Ca2+ exchange. However, out data can not rule out the other hypotheses explaining the increased c...Continue Reading


Mar 1, 1977·The Journal of Clinical Investigation·D Schachter, M Shinitzky
Nov 2, 1976·Biochemistry·S J Shattil, R A Cooper
Apr 1, 1988·The American Journal of the Medical Sciences·G Rinaldi, D Bohr
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May 1, 1957·American Journal of Clinical Pathology·B ZAK

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May 23, 1998·The International Journal of Biochemistry & Cell Biology·B C KonerD Dash
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