Modifications of the follicle-associated epithelium by short-term exposure to a non-intestinal bacterium

The Journal of Pathology
C BorghesiC Nicoletti

Abstract

This study was undertaken in order to study the effects of short-term exposure of the follicle-associated epithelium (FAE) of rabbit Peyer's patches to a non-intestinal, Gram-positive bacterium. Isolated ileal loops, each containing one Peyer's patch (PP), were stimulated for short periods of time (30 and 60 min) with Streptococcus pneumoniae R36a, a micro-organism normally not present in the intestinal area. Samples from antigen-stimulated and control Peyer's patches were analysed by light (LM), transmission electron (TEM), and scanning electron microscopy (SEM). Stimulation with living pneumococci induced dramatic changes in FAE architecture and morphology. A massive passage of cells from lymphoid tissue to the FAE was rapidly detectable, accompanied by alterations of the FAE surface, with a marked increase of M-cell area. Furthermore, TEM analysis revealed that M cells were able to internalize living pneumococci. S. pneumoniae R36a is a valid experimental model for the further study of the unique antigen sampling function which characterizes the highly specialized FAE in Peyer's patches.

References

Jan 1, 1990·Gastroenterology·P SicińskiG Koch
Jan 1, 1984·Annual Review of Medicine·J L Wolf, W A Bye
Oct 1, 1980·The American Journal of Anatomy·M W SmithI S King
Oct 1, 1980·The American Journal of Anatomy·M W Smith, M A Peacock
Jul 1, 1994·The Journal of Experimental Medicine·R L Owen
Mar 1, 1993·Cell and Tissue Research·M A JepsonB H Hirst

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Citations

Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Myoung Ho JangHiroshi Kiyono
Oct 18, 2000·Gut·C Nicoletti
Jun 9, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Xingwu ZhongXiaodong Zhou
Dec 5, 2015·Journal of Biochemistry·Hiroshi Ohno
Dec 26, 2003·The American Journal of Pathology·Andreas GebertKarl-Heinz Wendlandt
Jul 18, 2014·Bioscience of Microbiota, Food and Health·Takashi Kanaya, Hiroshi Ohno
Oct 24, 2006·Annals of the New York Academy of Sciences·Elisabet Gullberg, Johan D Söderholm
Nov 22, 2005·Expert Opinion on Drug Delivery·Monjed ShakwehElias Fattal
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Miao WangYongguang Zhang
Dec 29, 2010·International Journal of Inflammation·Camille JungFrédérick Barreau
Oct 6, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A Gebert, W Posselt
Apr 14, 2006·Veterinary Research·Masahiro YasudaJohn D Reynolds
Aug 14, 2010·Current Gastroenterology Reports·Joseph M Pickard, Alexander V Chervonsky
Oct 28, 2019·Traffic·Takashi KanayaHiroshi Ohno
Jan 5, 2002·Clinical and Diagnostic Laboratory Immunology·Mona AleksandersenThor Landsverk
Mar 10, 2001·Clinical and Diagnostic Laboratory Immunology·L Plant, P Conway
Mar 30, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H M MeynellC Nicoletti
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn A MatthiasJeffrey N Weiser
Feb 19, 1998·Alimentary Pharmacology & Therapeutics·J P KraehenbuhlM R Neutra
Sep 24, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Alessandro CarapelliEugenio Bertelli
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela L ManClaudio Nicoletti
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jing WangDavid D Lo
Mar 31, 2000·Trends in Cell Biology·F Niedergang, J P Kraehenbuhl

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