PMID: 10730740Mar 24, 2000

Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
S TakahashiH Toyooka

Abstract

To examine the effect of landiolol (ONO-1101), a new ultra-short acting, highly selective beta1 blocker, on hemodynamic response to acute theophylline intoxication in anesthetized dogs. Thirty-four dogs were studied during halothane anesthesia. Aminophylline (50 mg x kg(-1) over 20 min followed by infusion at 1.75 mg x kg(-1) x hr(-1)) was administered as a model of acute theophylline intoxication. Dogs were randomly enrolled into four landiolol groups (0, 1, 10, 100 microg x kg(-1) x min(-1)) to treat tachyarrhythmias. Hemodynamic variables, heart rate (HR), systemic blood pressure (SBP), pulmonary artery pressure, pulmonary artery occlusion pressure, and cardiac output (CO) were measured along with plasma concentrations of theophylline, epinephrine, and norepinephrine. After 60 min, plasma concentration of theophylline reached 46.6+/-4.0 (mean +/- SD) microg x ml(-1), HR increased from 129+/-21 to 193+/-27 bpm (P<0.0001) and CO increased from 1.6+/-0.5 l x min(-1) to 2.1+/-0.4 l x min(-1) (P<0.0001), whereas SBP decreased from 139+/-25 to 121+/-25 mm Hg (P<0.0001), with decreasing systemic vascular resistance. After intoxication, plasma epinephrine concentration increased from 125 +/-112 to 325+/-239 pg x ml(-1) (P<0.0001), a...Continue Reading

References

May 1, 1977·The Journal of Pediatrics·Y VaucherP D Walson
Jun 1, 1992·Chemical & Pharmaceutical Bulletin·S IguchiM Kawamura
Dec 1, 1990·Anesthesia and Analgesia·A DysonJ M Lipton
Feb 1, 1989·Anesthesia and Analgesia·M I GoldC A Skillman
Jun 1, 1985·Annals of Internal Medicine·T E KearneyM G Ziegler
Dec 1, 1987·Annals of Emergency Medicine·G G GaarA R Laddu
Dec 31, 1997·The American Journal of Cardiology·M J Kendall
Jul 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S TakahashiH Toyooka

Citations

Oct 4, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S TakahashiH Toyooka
Oct 12, 2012·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Donald R Miller

Related Concepts

Landiolol
Adrenergic beta-Antagonists
Adrenergic Agonists
Corophyllin
Cardiac Depressants
Diastolic Blood Pressure
Cardiac Output
Canis familiaris
Medihaler-Epi
Narcotan

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