Modified abbreviated burn severity index as a predictor of in-hospital mortality in patients with inhalation injury: development and validation using independent cohorts.

Surgery Today
Ryo YamamotoJunichi Sasaki

Abstract

The ability to accurately evaluate the severity of inhalation injury can help to optimize patient care. However, there is no accepted severity grading system, especially for inhalation injury. We screened a multicenter burn registry and included adult patients who required oxygen treatment or mechanical ventilation. After the patient data were divided into development and validation cohorts, missing values were replaced with multiple imputation. Twelve potential predictors were analyzed using multivariate logistic regression to identify prognostic variables for in-hospital mortality and scores were assigned to each predictor based on odds ratios to develop the Modified Abbreviated Burn Severity Index, mABSI. The mABSI was validated using c-statistics and calibration curves. We randomly assigned 1377 and 919 patients to the development and validation cohorts, respectively. Age, self-inflicted injury, cutaneous burn area, and mechanical ventilation requirement were identified as independent predictors, and the mABSI (1-17 scale) was, thus, developed. The mABSI has a high discriminatory power (c-statistic = 0.94; 95% CI 0.92-0.97), and both estimated and observed in-hospital mortalities increased from 1% at score ≤ 5 to almost 100...Continue Reading

References

May 1, 1982·Annals of Emergency Medicine·J TobiasenR F Edlich
Jan 11, 2005·Burns : Journal of the International Society for Burn Injuries·Eun J ChangJeffrey R Saffle
Mar 19, 2005·Burns : Journal of the International Society for Burn Injuries·G LiffnerF Sjöberg
Jul 5, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jeffrey D KerbyLoring W Rue
May 22, 2007·Journal of Burn Care & Research : Official Publication of the American Burn Association·Tina L Palmieri, Matthew B Klein
Nov 21, 2008·Burns : Journal of the International Society for Burn Injuries·Rita GaleirasAndrés Esteban
Dec 9, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Tina L Palmieri
Dec 9, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Lee C Woodson
Dec 26, 2008·The British Journal of Surgery·UNKNOWN Belgian Outcome in Burn Injury Study Group
Jan 24, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Rachel S LundgrenMatthew B Klein
Mar 27, 2010·Journal of Clinical Epidemiology·Kristel J M JanssenKarel G M Moons
Jun 5, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Shannon M Colohan
Sep 24, 2011·Burns : Journal of the International Society for Burn Injuries·N N SheppardP Dziewulski
Nov 10, 2011·Critical Care Medicine·Joslyn M AlbrightElizabeth J Kovacs
Jan 17, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Natasha A ForsterMerlin Guggenheim
Feb 22, 2012·Burns : Journal of the International Society for Burn Injuries·Christos IkonomidisMette M Berger
Mar 20, 2012·Critical Care Medicine·Colleen M RyanRobert L Sheridan
Oct 5, 2012·The New England Journal of Medicine·Roderick J LittleHal Stern
Nov 20, 2012·Annals of Surgery·Christopher S DavisElizabeth J Kovacs
Feb 7, 2013·Burns : Journal of the International Society for Burn Injuries·Amer HussainKen Dunn
Sep 18, 2013·Burns : Journal of the International Society for Burn Injuries·D P Mackie
Nov 20, 2014·Burns : Journal of the International Society for Burn Injuries·Kicheol YouJong-Hyun Kim
Jun 30, 2015·Burns : Journal of the International Society for Burn Injuries·Takashi TagamiHideo Yasunaga
Oct 29, 2015·Critical Care : the Official Journal of the Critical Care Forum·Patrick F WalkerKevin K Chung
Nov 26, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Stefania SpanoRobert Cartotto
Apr 1, 2016·The Journal of Trauma and Acute Care Surgery·Naveen F SangjiHaytham M A Kaafarani
Mar 23, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kevin N Foster, James H Holmes
May 2, 2017·PloS One·Antonio Palazón-BruVicente Francisco Gil-Guillén

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