Modified aging of elite athletes revealed by analysis of epigenetic age markers

Aging
M SpólnickaWojciech Branicki

Abstract

Recent progress in epigenomics has led to the development of prediction systems that enable accurate age estimation from DNA methylation data. Our objective was to track responses to intense physical exercise of individual age-correlated DNA methylation markers and to infer their potential impact on the aging processes. The study showed accelerated DNA hypermethylation for two CpG sites in TRIM59 and KLF14. Both markers predicted the investigated elite athletes to be several years older than controls and this effect was more substantial in subjects involved in power sports. Accordingly, the complete 5-CpG model revealed age acceleration of elite athletes (P=1.503x10-7) and the result was more significant amongst power athletes (P=1.051x10-9). The modified methylation of TRIM59 and KLF14 in top athletes may be accounted for by the biological roles played by these genes. Their known anti-tumour and anti-inflammatory activities suggests that intense physical training has a complex influence on aging and potentially launches signalling networks that contribute to the observed lower risk of elite athletes to develop cardiovascular disease and cancer.

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Citations

Aug 28, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Calen P Ryan
Jul 15, 2020·International Journal of Legal Medicine·Barbara Elisabeth KoopStefanie Ritz-Timme
Mar 27, 2020·Frontiers in Bioengineering and Biotechnology·Xiaoqian GaoFengfeng Zhou
Aug 28, 2019·International Journal of Environmental Research and Public Health·Sofia PavanelloSabino Iliceto
Dec 18, 2020·Journal of Sport and Health Science·Guiling WuFeng Gao
Mar 9, 2021·Ageing Research Reviews·Rezvan NorooziEwelina Pośpiech
Aug 19, 2021·International Journal of Legal Medicine·Danuta Piniewska-RógUNKNOWN VISAGE Consortium

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Methods Mentioned

BETA
Assay

Software Mentioned

DNAm
SPSS Statistics

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