Modified bacterial cellulose scaffolds for localized doxorubicin release in human colorectal HT-29 cells

Colloids and Surfaces. B, Biointerfaces
Maximiliano L CacicedoGuillermo R Castro

Abstract

Bacterial cellulose (BC) films modified by the in situ method with the addition of alginate (Alg) during the microbial cultivation of Gluconacetobacter hansenii under static conditions increased the loading of doxorubicin by at least three times. Biophysical analysis of BC-Alg films by scanning electron microscopy, thermogravimetry, X-ray diffraction and FTIR showed a highly homogeneous interpenetrated network scaffold without changes in the BC crystalline structure but with an increased amorphous phase. The main molecular interactions determined by FTIR between both biopolymers clearly suggest high compatibility. These results indicate that alginate plays a key role in the biophysical properties of the hybrid BC matrix. BC-Alg scaffold analysis by nitrogen adsorption isotherms revealed by the Brunauer-Emmett-Teller (BET) method an increase in surface area of about 84% and in pore volume of more than 200%. The Barrett-Joyner-Halenda (BJH) model also showed an increase of about 25% in the pore size compared to the BC film. Loading BC-Alg scaffolds with different amounts of doxorubicin decreased the cell viability of HT-29 human colorectal adenocarcinoma cell line compared to the free Dox from around 95-53% after 24h and from 63%...Continue Reading

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Citations

Mar 2, 2016·Bioresource Technology·Maximiliano L CacicedoGuillermo R Castro
May 3, 2019·Journal of Biomaterials Science. Polymer Edition·Nadda ChiaoprakobkijMuenduen Phisalaphong
Nov 19, 2019·Macromolecular Rapid Communications·Yee Yee KhineMartina H Stenzel
Aug 22, 2017·Therapeutic Delivery·Yvette PötzingerDagmar Fischer
Jan 25, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Archana A GuptaPeter A Brennan
Sep 2, 2020·Advances in Wound Care·Wei HeSiming Yang
Feb 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shuo ZhangShaofeng Rong
Jan 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rui-Zhi TangXi-Qiu Liu
Nov 19, 2019·International Journal of Biological Macromolecules·Maximiliano L CacicedoGuillermo R Castro
Jan 18, 2021·International Journal of Biological Macromolecules·Saman Emami GeramiMona Navaei Nigjeh
Nov 23, 2018·Acta Biomaterialia·Lila AutierPhilippe Menei
Jun 8, 2017·International Journal of Biological Macromolecules·Guilherme Fadel PichethRilton Alves de Freitas

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