Modified chitosan-based bioactive material for antimicrobial application: Synthesis and characterization

International Journal of Biological Macromolecules
Elton Marks de Araújo BrazEdson Cavalcanti da Silva Filho

Abstract

The search for natural antibacterial agents to treat diseases caused by resistant microorganisms has been gaining increasing attention. Chitosan has been studied in several areas due to its particular properties. The grafting of hydrophobic chains into the chitosan molecule, turning it amphiphilic, may improve its antimicrobial activity by increasing electrostatic interaction with the bacterial cell wall. The objective of this work was to enhance the antimicrobial activity of chitosan by the reaction of N-acylation with maleic anhydride. For this purpose, molar ratios of 1:2, 1:5 and 1:10 chitosan: anhydride were investigated, and the obtained derivatives were characterized by elemental analysis, FTIR, thermal analysis and XRD where it was possible to prove the chemical modification of chitosan. The modified materials presented excellent antibacterial action against Staphylococcus aureus and Escherichia coli, evidencing no activity against the protozoan Leishmania amazonensis. Cytotoxicity assays by the MTT analysis and hemolysis indicated that the derivatives did not show toxicity in mammalian cells. The proposed modified chitosan compounds showed to be promising for biomedical applications since they allied excellent antibact...Continue Reading

Citations

Dec 28, 2019·Polymers·Silvestru Bogdănel Munteanu, Cornelia Vasile
Sep 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Philippe M LoiseauSimon L Croft
Nov 7, 2019·Materials·Luciano C B LimaEdson C Silva-Filho
Dec 29, 2020·Carbohydrate Polymers·Antônia Carla de Jesus OliveiraMônica Felts de La Roca Soares
Feb 23, 2020·International Journal of Biological Macromolecules·Shadpour Mallakpour, Mohaddeseh Abbasi
Nov 5, 2020·Carbohydrate Polymers·Solranny Carla Cavalcante Costa SilvaEdson C Silva-Filho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.