PMID: 16639867Apr 28, 2006Paper

Modified dexamethasone suppression-corticotropin-releasing hormone stimulation test: A pilot study of young healthy volunteers and implications for alcoholism research in adolescents and young adults

International Journal of Adolescent Medicine and Health
Leo SherMaria A Oquendo

Abstract

The key neuroendocrine component of a response to stress is the hypothalamic-pituitary-adrenocortical (HPA) system. Abnormalities in the HPA system have been implicated in the pathophysiology of psychiatric disorders such as depression, post-traumatic stress disorder, alcoholism and suicide. The dexamethasone suppression test (DST) is the most frequently used test to assess HPA-system function in psychiatric disorders. This neuroendocrine test consists of the administration of a low dose of dexamethasone at 11 pm and the measurement of cortisol levels at one or more time points on the following day. After corticotropin-releasing hormone (CRH) became available for clinical studies, the DST was combined with CRH administration. In this test, patients are pretreated with a single dose of dexamethasone at 11 pm and receive human CRH intravenously at 3 pm the following day. The resulting DST-CRH test proved to be much more sensitive in detecting HPA system alterations than the DST. We have modified the DST-CRH test and used ovine CRH instead of human CRH in a pilot study of a group of young healthy volunteers. Results indicated that it produces results similar to the results obtained with human CRH. This suggests that ovine CRH can ...Continue Reading

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Citations

Feb 23, 2010·European Archives of Psychiatry and Clinical Neuroscience·Maurizio PompiliDavid Lester
Oct 24, 2007·Peptides·Richard J Bodnar
Jul 1, 2017·Proceedings. Biological Sciences·Mingwang ShenSteven E Bellan
Aug 15, 2014·International Journal of STD & AIDS·Pernille S PettersenAsgeir Johannessen
Jun 29, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Carolina D WienerJean P Oses

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