PMID: 3712386Jun 1, 1986

Modified di- and tripeptides of the C-terminal portion of oxytocin and vasopressin as possible cognition activation agents

Journal of Medicinal Chemistry
E D NicolaidesR E Voigtman

Abstract

A number of peptides and modified peptides were synthesized and studied for their ability to reverse electroconvulsive shock-induced amnesia in rodents. A few of these peptides were selected for secondary evaluation in tests of short-term memory in rats and aged rhesus monkeys. A number of the peptides and modified peptides were active in the amnesia reversal test. In selected secondary tests, however, the chosen compounds failed to show significant activity in enhancing memory. New methods for preparing methyleneamino and methyleneoxy isosteres of peptides are reported. Other modified peptides also included methylenethio, methylenesulfonyl, and ethylene isosteres in place of the normal peptide amide bond.

Citations

Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Merlini, M Pinza
Oct 24, 1996·European Journal of Pharmacology·Z HlinákE Kasafírek
May 12, 2007·Chembiochem : a European Journal of Chemical Biology·Yazmín T Rosa-BauzáJonathan A Ellman
Apr 1, 1990·International Journal of Peptide and Protein Research·P BretonR Mayer
Jul 1, 1988·Medicinal Research Reviews·W H MoosE R Gamzu
Jan 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Spyridon MourtasKleomenis Barlos

Related Concepts

Cognition
Macaca mulatta
Immediate Recall
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