Modified histologic grading of neuroblastomas by replacement of mitotic rate with mitosis karyorrhexis index. A clinicopathologic study of 223 cases from the Pediatric Oncology Group

Cancer
V V JoshiR P Castleberry

Abstract

Histologic grading (HG) of neuroblastomas (NB) of prognostic significance is based on the presence of absence of calcification and low mitotic rate ( < or = 10/10 high power fields). Mitosis karyorrhexis Index (MKI) is the main feature used for prognostic categorization in Shimada classification and can be determined more readily than mitotic rate (MR). The purpose of this study is to test whether MKI can be used instead of MR for histologic grading. Low and intermediate MKI were lumped together as low MKI. We replaced MR with the modified MKI categories. Histologic grades for 223 NBs registered with the Pediatric Oncology Group protocols 8104 and 8441, were defined ad follows: HG 1 = calcification + low MKI, HG 2 = calcification or low MKI, HG 3 = high MKI and absence of calcification. Shimada classification was also determined for comparison or modified HGs with favorable histology (FH) and unfavorable histology (UH), HGs were linked with age: low risk (LR) = HG 1 in all age groups + HG 2 in patients age younger than 1 year; high risk (HR) = HG 2 in patients age 1 year of older + HG 3 in all age groups. Statistically significant differences in 5-year survival were seen in the NBs of different modified HG (1: 92.7%, 2: 74.9%, ...Continue Reading

References

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Citations

Feb 18, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Joseph PierseJessica Wollenberg
Nov 5, 1997·Annals of the New York Academy of Sciences·V V Joshi, G J Tsongalis
Aug 1, 1997·Pediatric Clinics of North America·R P Castleberry
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samuel NavarroUNKNOWN European Study Group 94.01 Trial and Protocol
May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I M AmbrosP F Ambros
Aug 7, 2008·Journal of Clinical Pathology·H C MooreD A Tweddle
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M LastowskaUNKNOWN United Kingdom Children Cancer Study Group and the United Kingdom Cancer Cytogenetics Group
Apr 25, 2000·Indian Journal of Pediatrics·S Shah, Y Ravindranath

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