Modified hydrated sodium calcium aluminosilicate-supplemented diet protects porcine oocyte quality from zearalenone toxicity.

Environmental and Molecular Mutagenesis
Yao XuShao-Chen Sun

Abstract

Zearalenone (ZEN) is one of the most common mycotoxins produced by fungus in contaminated feed. ZEN has multiple toxicities, including reproductive toxicity of domestic animals, particularly pigs. However, studies on the effects of ZEN on ovary/oocytes have been primarily based on in vitro experiments, and there is still no evidence from porcine in vivo models due to multiple limitations. Moreover, no report has investigated the effect of hydrated sodium calcium aluminosilicate (HSCAS) as a supplement on pig oocyte quality. In the present study, we fed pigs a 1.0 mg/kg ZEN-contaminated diet for 10 days. The results showed that pigs fed ZEN presented reduced oocyte-cumulus cell interactions, an increase in the number of denuded oocytes in ovaries, a decrease in the number of oocytes in each ovary, and an increase in the oocyte death rate. Oocytes from ZEN-exposed pigs exhibited a delayed cell cycle and abnormal cytoskeletal dynamics during meiotic maturation, which could be due to oxidative stress-induced autophagy. Moreover, we also show that supplementing the ZEN-contaminated diet with modified HSCAS effectively protected porcine oocyte quality. Taken together, our study provides in vivo data demonstrating the protective effec...Continue Reading

References

Sep 1, 1987·Regulatory Toxicology and Pharmacology : RTP·T Kuiper-GoodmanH Watanabe
Jul 1, 1982·Journal of Animal Science·M Etienne, M Jemmali
Jan 1, 1984·Australian Veterinary Journal·B J BlaneyC J Moore
Jul 6, 2001·Toxicology Letters·A HuwigH Dutler
Oct 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abdellah ZinedineJordi Mañes
Nov 14, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Hitomi TakemuraKayoko Shimoi
Mar 31, 2009·International Journal of Molecular Sciences·Fiorenza Minervini, Maria Elena Dell'Aquila
May 2, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaru Iwai, Masatsugu Horiuchi
Jan 22, 2013·Arhiv za higijenu rada i toksikologiju·Agnieszka WaśkiewiczPiotr Goliński
Dec 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wei YangLiegang Liu
Feb 18, 2014·Toxicology Letters·Yajun WangJianchun Bian
Apr 16, 2014·Environmental Toxicology·Yan-Jun HouShao-Chen Sun
Aug 27, 2014·Mutagenesis·Cheng-Cheng ZhuShao-Chen Sun
Mar 20, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy S BianeJames M Conner
Sep 20, 2015·Toxicology and Applied Pharmacology·Fang-Nong LaiWei Shen
Feb 18, 2017·Toxins·Sabina B BinderFranz Berthiller

❮ Previous
Next ❯

Citations

May 26, 2021·Molecular Reproduction and Development·Jiehuan XuJianjun Dai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms