Modified hydroxypropyl methyl cellulose: Efficient matrix for controlled release of 5-amino salicylic acid

International Journal of Biological Macromolecules
Raghunath Das, Sagar Pal

Abstract

Hydroxypropyl methyl cellulose has been modified by grafting synthetic polyacrylamide chains [g-HPMC (M)] in presence of microwave irradiation, which has used as carrier for controlled release of 5-amino salicylic acid (5-ASA). The FTIR and UV-vis-NIR studies reveal the excellent compatibility between g-HPMC (M) and 5-ASA. Field emission scanning electron microscopy (FESEM) and UV-vis-NIR analyses suggest that physical interaction predominates between the drug and matrix. % equilibrium swelling ratio (% ESR) of g-HPMC (M) decreased with addition of salt solutions and follow the order: Na(+)>K(+)>Mg(2+)>Ca(2+)>Al(3+). The in vitro 5-ASA release studies indicate that g-HPMC (M) delivers the drug preferentially in colonic region in more sustained way than that of HPMC. The 5-ASA release follows first order kinetics and non-Fickian diffusion mechanism. These favorable features make the graft copolymer a potential matrix for colon specific delivery of 5-ASA.

References

Mar 4, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·M Z KhanN Kurjaković
Apr 1, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·S DavaranA Khosravi
Nov 24, 2004·Advanced Drug Delivery Reviews·David R Friend
Oct 20, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anne des RieuxVéronique Préat

❮ Previous
Next ❯

Citations

Jul 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pedro M VelosoClarisse Nobre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here