Modified magnetic nanoparticles by PEG-400-immobilized Ag nanoparticles (Fe3 O4 @PEG-Ag) as a core/shell nanocomposite and evaluation of its antimicrobial activity

International Journal of Nanomedicine
Kamiar ZomorodianHojat Veisi

Abstract

Noble metal nanoparticles, due to their good physicochemical properties, have been exploited in biological applications. Among these metals, nanosilver has attracted great attention because of its optical properties and broad-spectrum antimicrobial activities with no drug tolerance. The present study has attempted to conduct chemical synthesis of Fe3O4@PEG-Ag core/shell nanocomposites in aqueous solutions through co-precipitation of Fe3+ and Fe2+ ions, encapsulating the iron oxide core by poly (ethylene-glycol) (PEG) improve its hydrophilicity and biocompatibility, and immobilizing silver ions by application of NaBH4 as a reducing agent. The synthesized structures were characterized by Fourier-transform infrared (FT-IR), field emission scanning electron microscopy, energy-dispersive X-ray spectrum, wavelength-dispersive X-ray, vibrating sample magnetometer, inductively coupled plasma-mass spectrometry and transmission electron microscopy methods. Antimicrobial activity of the nanostructures against Staphylococcus aureus, Escherichia coli and Candida albicans was evaluated by broth microdilution based on the methods suggested by Clinical Laboratory Standard Institute. Furthermore, the nanocomposite was tested for possible anti-p...Continue Reading

Citations

Jul 6, 2019·Frontiers in Bioengineering and Biotechnology·Chen XuAiguo Wu
Oct 24, 2019·Current Topics in Medicinal Chemistry·Huiqiong JiaZhi Ruan
Dec 16, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Xin HuangBingdi Chen
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena KędzierskaBożena Tyliszczak
Jun 4, 2021·International Journal of Pharmaceutics·Olga Kammona, Evgenia Tsanaktsidou

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Methods Mentioned

BETA
atomic force microscopy
AFM
enzyme-linked immunosorbent assay
scanning electron microscopy
transmission electron microscopy
scanning
X-ray
surface plasmon resonance

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