Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans -anhydromevalonate 5-phosphate

Proceedings of the National Academy of Sciences of the United States of America
Hajime HayakawaHisashi Hemmi

Abstract

The modified mevalonate pathway is believed to be the upstream biosynthetic route for isoprenoids in general archaea. The partially identified pathway has been proposed to explain a mystery surrounding the lack of phosphomevalonate kinase and diphosphomevalonate decarboxylase by the discovery of a conserved enzyme, isopentenyl phosphate kinase. Phosphomevalonate decarboxylase was considered to be the missing link that would fill the vacancy in the pathway between mevalonate 5-phosphate and isopentenyl phosphate. This enzyme was recently discovered from haloarchaea and certain Chroloflexi bacteria, but their enzymes are close homologs of diphosphomevalonate decarboxylase, which are absent in most archaea. In this study, we used comparative genomic analysis to find two enzymes from a hyperthermophilic archaeon, Aeropyrum pernix, that can replace phosphomevalonate decarboxylase. One enzyme, which has been annotated as putative aconitase, catalyzes the dehydration of mevalonate 5-phosphate to form a previously unknown intermediate, trans-anhydromevalonate 5-phosphate. Then, another enzyme belonging to the UbiD-decarboxylase family, which likely requires a UbiX-like partner, converts the intermediate into isopentenyl phosphate. Thei...Continue Reading

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Citations

Jan 24, 2019·Extremophiles : Life Under Extreme Conditions·Geraldy L S LimanThomas J Santangelo
Mar 3, 2019·Applied and Environmental Microbiology·Kento MotoyamaHisashi Hemmi
Jan 17, 2021·Applied and Environmental Microbiology·Jared AldridgeNicole R Buan
Feb 26, 2021·ChemSusChem·Godwin A AlekuDavid Leys
Sep 4, 2020·Biotechnology Advances·Yuyao RenYongjin J Zhou
Jun 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yosuke Hoshino, Eric A Gaucher
Jul 8, 2021·Natural Product Reports·Mauro A RinaldiNigel S Scrutton
Dec 24, 2019·Journal of Agricultural and Food Chemistry·Xixian ChenNicholas D Lindley
Jul 4, 2019·ACS Chemical Biology·Suzanne T ThomasJoseph P Noel
Dec 6, 2021·Bioscience, Biotechnology, and Biochemistry·Yumi IshibashiHisashi Hemmi
Jan 14, 2022·Proceedings of the National Academy of Sciences of the United States of America·Hiroyuki D SakaiNorio Kurosawa

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