Modified microbiological assay for rapid estimation of antibiotic concentrations in human sera.

Applied Microbiology
S A Stroy

Abstract

Antibiotic concentrations in human sera were estimated in 5 to 6 hr by a modified microbiological assay. By using Staphylococcus aureus and Streptococcus pyogenes as the assay organisms, the seeded assay plates were preincubated for 2 to 6 hr and then were stored at 4 C until used for assay. Paper discs saturated with the specimen were placed on the preincubated assay plates with reference discs saturated with known concentrations of antibiotic. After 5 to 6 hr of incubation, zones of antibacterial activity were measured and compared with a standard curve for estimation of antibiotic concentration. Results from this rapid assay method compared favorably with those from the commonly used 24-hr assay.

Citations

May 1, 1974·Antimicrobial Agents and Chemotherapy·D F LibermanR G Robertson
Nov 1, 1973·Antimicrobial Agents and Chemotherapy·M E LundJ M Matsen
Jan 1, 1972·Antimicrobial Agents and Chemotherapy·E WarrenI I Washington JA

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