PMID: 6171997Jan 1, 1981Paper

Modified Nauta and Fink-Heimer procedures with special reference to the demonstration of monoaminergic pathways in the central nervous system

Acta Physiologica Et Pharmacologica Bulgarica
K G UsunoffG P Galabov

Abstract

Modifications of the selective silver impregnation methods of Nauta and Fink-Heimer are described. Both procedures were tested in wide variety of species: from reptiles to carnivores, as well as in human autoptic cases. The modified Nauta procedure is recommended as a method of choice for tracing axonal trajectories due to an improved impregnation selectivity of the degenerating axoplasm. Its use for the demonstration of monoaminergic (NA, DA, 5-HT) pathways, however, remains limited. The modified Fink-Heimer procedure demonstrates successfully the degeneration of axons, and especially--the thin preterminal arborizations, as well as the terminal boutons in many fiber systems studied, including the nigrostriatal, raphe-nigral, and coerulocortical tracts. Both methods provide an additional cytoarchitectonic orientation due to a counterstain of nerve cell bodies with cresylechtviolett.

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