Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC

American Journal of Hematology
Hideo WadaJapanese Society of Thrombosis Hemostasis/DIC subcommittee

Abstract

Diagnostic criteria for non-overt disseminated intravascular coagulation (DIC) have been proposed by the International Society of Thrombosis and Hemostasis, but are not useful for the diagnosis of early phase of overt-DIC (pre-DIC). Therefore, in the current study the non-overt DIC diagnostic criteria were modified using the global coagulation tests, the change rate in the global coagulation tests and molecular hemostatic markers to detect the pre-DIC state and were prospectively evaluated in 613 patients with underlying DIC disease. The frequencies of patients with DIC (DIC positive), late onset DIC, and without DIC (DIC absent) were 29.5%, 7.2%, and 63.3%, respectively. The modified non-overt-DIC criteria can correctly predict 43/44 patients (97.7%) who were DIC absent at admission and became DIC positive, within a week (late onset DIC state). The mortality rate was higher in DIC positive compared with pre-DIC (37.6% vs. 22.7%, P < 0.05) or DIC negative (37.6 vs. 13.7%, P < 0.01). It was also significantly higher in pre-DIC compared with DIC negative (P < 0.05). Thus, these modified non-overt DIC diagnostic criteria might therefore be useful for the diagnosis of early-phase DIC.

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Citations

Nov 23, 2011·Journal of Clinical and Experimental Hematopathology : JCEH·Toshihiro Kaneko, Hideo Wada
Sep 28, 2012·Internal and Emergency Medicine·Marcel Levi, Tom van der Poll
Nov 23, 2015·International Journal of Hematology·Takumi AotaNaoyuki Katayama
Feb 6, 2013·Journal of Thrombosis and Haemostasis : JTH·H WadaUNKNOWN The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis
Apr 23, 2014·International Journal of Laboratory Hematology·M Levi
Oct 19, 2010·Blood Reviews·Marcel Levi, Joost C Meijers
Nov 18, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Neha SinghRenu Saxena
Jul 4, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Shigeki KushimotoUNKNOWN Japanese Society of Thrombosis Hemostasis/DIC subcommittee
Jun 15, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Yutaka UmemuraSatoshi Fujimi
Jun 16, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Takumi AotaNaoyuki Katayama
Oct 13, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Takumi AotaNaoyuki Katayama
May 31, 2018·Journal of Thrombosis and Haemostasis : JTH·K SuzukiUNKNOWN Subcommittee on Disseminated Intravascular Coagulation
Dec 12, 2012·Expert Review of Hematology·Hideo WadaTuyoshi Hatada
Jan 15, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ali AlhousseiniOffer Erez
Oct 13, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ahmed A El-NawawyHanan F Nazir

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