PMID: 16613559Apr 15, 2006Paper

Modified recombinant allergens for safer immunotherapy

Inflammation & Allergy Drug Targets
Fátima FerreiraGernot Achatz

Abstract

Molecular cloning and recombinant production of allergens offered new perspectives for the increasing problem of allergies. A variety of preparations are being developed aiming to increase safety and improve efficacy of specific immunotherapy. Recombinant-based approaches are mostly focused on genetic modification of allergens to produce molecules with reduced allergenic activity and conserved antigenicity, i.e. hypoallergens. Studies dealing with genetic modifications of allergen genes reported the production of site-directed mutants, deletion mutants, allergen fragments and oligomers, and allergen chimeras. An alternative to genetic engineering is the chemical modification of pure recombinant allergens. It has been shown that allergens modified with immunostimulatory DNA sequences (allergen-ISS conjugates), which masks IgE epitopes and adds a desirable Th1-inducing character to the allergen molecule. Other chemical modifications include oligomerization by aldehydes (allergoids) and maleylation, which seems to target allergens to particular antigen presenting cells. Several of these modified allergen preparations have been already evaluated for their safety in clinical provocation studies. So far, clinical trials showed the ef...Continue Reading

Citations

Aug 11, 2006·Current Allergy and Asthma Reports·Robert E Esch
Jul 11, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Deidra A Blanks
Mar 3, 2010·Annual Review of Immunology·Rudolf ValentaSusanne Vrtala
Jan 19, 2013·Clinical Reviews in Allergy & Immunology·Yao-Hsu Yang, Bor-Luen Chiang
Dec 3, 2009·Biotechnology Letters·Marilisa BarrancaRiccardo Alessandro
Feb 7, 2007·Expert Review of Vaccines·Guoping Li, Bin Liao
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Oliver CromwellAndreas Nandy
Apr 8, 2010·The Journal of Allergy and Clinical Immunology·Theresa ThalhamerArnulf Hartl
Apr 10, 2009·The Journal of Allergy and Clinical Immunology·Véronique SchultenBarbara Bohle
Aug 16, 2015·International Journal of Biological Macromolecules·Najmeh Kazem-FarzandiThomas Haertlé
Sep 25, 2007·The Journal of Allergy and Clinical Immunology·Stefan WagnerHeimo Breiteneder
Jul 27, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Milan BlanusaTanja Cirkovic Velickovic
Jun 15, 2007·The Journal of Allergy and Clinical Immunology·Roberto González-RiojaJuan A Asturias
Feb 6, 2007·Immunology and Allergy Clinics of North America·Ke ZhangAndrew Saxon
Jul 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I LauerS Scheurer
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A AsturiasA Martínez
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WaldH Fiebig
Mar 20, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Rosa Codina, Richard F Lockey
Dec 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Gafvelin
Aug 19, 2015·Journal of Biotechnology·Asghar Taheri-KafraniThomas Haertlé
May 26, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Rosa CodinaRichard F Lockey
Jun 24, 2014·Yonsei Medical Journal·Fatima FerreiraMichael Wallner
Apr 14, 2011·Yonsei Medical Journal·Kyoung Yong JeongJung-Won Park
Oct 30, 2010·Current Opinion in Allergy and Clinical Immunology·Robert K Bush
Jan 31, 2012·International Archives of Allergy and Immunology·Véronique Bordas-Le FlochPhilippe Moingeon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Allergy and Clinical Immunology
Marek JutelOliver Cromwell
The Journal of Allergy and Clinical Immunology
Michael WallnerFátima Ferreira
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
S VrtalaR Valenta
Proceedings of the National Academy of Sciences of the United States of America
V NiederbergerR Valenta
© 2022 Meta ULC. All rights reserved