Modified vibrating-mesh nozzles for advanced spray-drying applications

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Moritz Beck-BroichsitterThomas Kissel

Abstract

This work describes uniform polymer coatings allowing for an adjustment of the orifice dimension of vibrating-mesh nozzles and therefore, size of emerging formulation droplets and dried particles, which is of general interest for diverse spray-drying applications. Chemical vapor deposition of poly(p-xylylene) (PPXN) on aperture templates of the B-90 spray-dryer (orifice diameters: ∼4.0μm) caused a reduction of the opening cross-sections of ∼50%. Thus, a more efficient formulation atomization was observed (finer droplets). Likewise, application of PPXN-coated, rather than plain nozzles, resulted in significantly smaller (particle diameter: 1.3 vs. 3.6μm) and narrower distributed (span: ∼1.4 vs. ∼1.8) sildenafil-loaded poly(lactide-co-glycolide) microparticles. Prediction of the size of spray-dried microparticles using the size results of atomized droplets ("residual core method") was shown to be in agreement with the observed values. Formulations prepared with plain and PPXN-coated nozzles exhibited a sustained sildenafil release profile with mean dissolution times of ∼1.5 and ∼4.0h, respectively. Regardless of the starting aperture template, any desired orifice dimension and therefore, dried particle size could be achieved by g...Continue Reading

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Citations

Jan 8, 2016·Pharmaceutical Development and Technology·Moritz Beck-BroichsitterThomas Kissel
Feb 7, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Moritz Beck-BroichsitterThomas Kissel
Feb 16, 2016·Journal of Microencapsulation·Soon Chuan WongKian Sek Tee
Apr 25, 2019·Macromolecular Bioscience·Ratchapol JenjobDaniel Crespy
Aug 25, 2020·Soft Robotics·Han-Joo LeeKenneth J Loh
Sep 23, 2021·Assay and Drug Development Technologies·A Alper Öztürk, Cordin Arpagaus

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