Modified Young's modulus of microcrystalline cellulose tablets and the directed continuum percolation model

Pharmaceutical Development and Technology
M Kuentz, H Leuenberger

Abstract

The purpose of this investigation was to analyze the modified Young's modulus of microcrystalline cellulose tablets at comparatively low relative densities, based on concepts of percolation theory. Tablets were prepared and tested using a Zwick 1478 universal testing instrument. For statistical evaluation a new method is introduced for power laws, which exhibits highly correlated model parameters. According to our results the model Leuenberger, Leu is consistent with an Effective Medium Approximation which exhibits an exponent equal to one far away from the percolation threshold. In addition, the results show that it is essential to evaluate the elastic behavior of tablets close to the percolation threshold. For the different types of MCC a critical exponent q = 3.95 +/- 0.14 was obtained. This result is very essential, as it is in good agreement with the theoretically expected value of 3.9 from an elastic network (central force model). The proposed model describes the modified Young's modulus better than former model equations taking into account the relative density. Thus, the process during uniaxial compaction can be imagined as a directed continuum percolation and the relative density of compacts can be identified as a spac...Continue Reading

References

Oct 1, 1992·Journal of Pharmaceutical Sciences·H Leuenberger, R Leu
Feb 1, 1990·Pharmaceutical Research·D BlattnerH Leuenberger

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Citations

May 13, 2015·Carbohydrate Polymers·Esra Erbas KiziltasDouglas J Gardner
Mar 27, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Virginie BusigniesPierre Tchoreloff
Mar 5, 2019·Journal of Microscopy·Matthias NeumannVolker Schmidt
Mar 26, 2019·Pharmaceutical Development and Technology·Saurabh M Mishra, Bhagwan D Rohera
Sep 8, 2019·Pharmaceutical Research·Renata Abreu-VillelaIsidoro Caraballo
Feb 9, 1999·Journal of Pharmaceutical Sciences·M Kuentz, H Leuenberger

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