Modifying Chromatin by Histone Tail Clipping

Journal of Molecular Biology
Gajendra Kumar AzadRaghuvir Singh Tomar

Abstract

Post-translational modifications (PTMs) of histone proteins play a crucial role in the regulation of chromatin structure and functions. Studies in the last few decades have revealed the significance of histone PTMs in key cellular processes including DNA replication, repair, transcription, apoptosis and cell cycle regulation. The PTMs on histones are carried out by chromatin modifiers, which are reversible in nature. The dynamic activity of chromatin modifiers maintains the levels of different PTMs on histones. The modified histones are recognized by reader proteins, which recruit effector proteins to regulate the function. The interplay between histone PTMs and chromatin dynamics plays a major role in the regulation of most of the cellular processes. Importantly, the perturbations in the histone PTMs by various intrinsic or extrinsic factors can cause defects in fundamental cellular processes leading to a wide range of diseases. The proteolytic clipping of histone proteins has also been shown to regulate many biological processes. Histone clipping has been observed from yeast to mammals, suggesting that this mechanism is a conserved epigenetic phenomenon. In this review, we have summarized the significance of histone clipping ...Continue Reading

Citations

Mar 5, 2020·Doklady. Biochemistry and Biophysics·N V MaluchenkoA V Feofanov
Apr 5, 2019·International Journal of Genomics·Alexander Vaiserman, Oleh Lushchak
Jan 6, 2021·Nucleic Acids Research·Karin Johanna FerrariDiego Pasini
Nov 19, 2020·Molecular & Cellular Proteomics : MCP·Congcong LuBenjamin A Garcia
Dec 7, 2020·Current Opinion in Structural Biology·Yunhui PengAnna R Panchenko
Jan 26, 2021·Frontiers in Oncology·Atsushi FujimuraLei Chang
Mar 1, 2020·Wiley Interdisciplinary Reviews. Computational Molecular Science·Stephanie Portillo-Ledesma, Tamar Schlick
Jun 9, 2021·Neurobiology of Disease·Eduard DauraTarja Joensuu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Nature Structural & Molecular Biology
Gabriel E Zentner, Steven Henikoff
Methods in Molecular Biology
Javier Rodríguez-Ubreva, Esteban Ballestar
© 2022 Meta ULC. All rights reserved