PMID: 589871Nov 1, 1977

Modifying effect of bradykinin on motor activity in the guinea-pig gall bladder

Clinical and Experimental Pharmacology & Physiology
J StasiewiczA Gabryelewicz

Abstract

1. The interaction of bradykinin and cholecystokinin preparations was investigated on the guinea-pig isolated gall bladder. Bradykinin (1-100 ng/ml) induced dose-dependent contractile effects which were considerably smaller than those produced by cholecystokinin octapeptide. Bradykinin in a low concentration (1.0 ng/ml) caused a significant increase of the contraction induced by cholecystokinin octapeptide (P less than 0.001) and natural cholecystokinin-pancreozymin (P less than 0.01), and also augmented the effects of acetylcholine on this preparation. Therefore these effects are probably not specific for cholecystokinin.

References

Jan 1, 1974·Pharmacology·J Moniuszko-JakoniukA Bodzenta
Aug 1, 1969·Scandinavian Journal of Clinical and Laboratory Investigation·P O Ganrot, J E Niléhn
May 1, 1969·Scandinavian Journal of Clinical and Laboratory Investigation·S P Nielsen
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·A Antonio
Jan 1, 1969·British Journal of Pharmacology·K Buluk, M Malofiejew
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·E W HORTON

Citations

Nov 1, 1989·Digestive Diseases and Sciences·D GermanD L Kaminski

Related Concepts

Acetylcholine Sulfate (1: 1)
Bradykinin Hydrochloride
CCK-33
Gallbladder
Cavia porcellus
Inotropism
Smooth Muscle

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