PMID: 3771626Jan 1, 1986Paper

Modifying effects of disulfiram on DNA adduct formation and persistence of benzaldehyde in N-nitroso-N-methyl-benzylamine-induced carcinogenesis in rats

Journal of Cancer Research and Clinical Oncology
F SchweinsbergV Bürkle

Abstract

Whereas disulfiram (DSF) is known to inhibit tumor formation resulting from a number of chemical carcinogens, such inhibition does not apply to nitrosamines. In the present study, biochemical and morphological findings were examined to elucidate the effect of DSF on long-term application of N-nitroso-N-methylbenzylamine (NMBA). HPLC and fluorescence detection were used to determine O6-methylguanine (O6-MG) in DNA obtained from the respiratory tract of rats subjected to long-term simultaneous application of DSF and NMBA. After 2 days of treatment, more O6-MG was detected in the proximal portion of the respiratory tract, including the trachea and main bronchi, than in the distal portion. The findings were reversed after 10 and 30 days, at which time formation of the DNA adduct was substantially higher in the distal portion of the respiratory tract, despite increases in both portions. The biochemical results corresponded to morphological findings. Initially, increased numbers of metabolizing goblet cells appeared in mucous cell hyperplasia in the proximal respiratory tract. Subsequently, the hyperplasia migrated to distal regions of the respiratory tract; at this stage, the goblet cells disappeared from the proximal portion, which...Continue Reading

Citations

Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·F Schweinsberg, V Bürkle
Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·D HadjiolovK Spirov
Sep 15, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiD K Wilcox
Dec 11, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eşref DemirBülent Kaya
Oct 24, 2008·Phytopathology·A D GeeringJ E Thomas
Oct 18, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang

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