Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment

Transplant International : Official Journal of the European Society for Organ Transplantation
Paulo N A MartinsStefan G Tullius

Abstract

Many studies have shown a strong association between initial graft injury and poor long-term graft outcome. Events initiated by unspecific immune-activating processes including brain death and ischemia/reperfusion injury occurring prior to transplantation reduce graft functionality and amplify the host immune response. These events may be particularly relevant for less than optimal grafts with reduced resistance to unspecific injuries. Several approaches to ameliorate immune activation of the graft by treating the donor or the graft have been studied. While various substances have been shown to have protective effects in experimental transplantation, only a few drugs have been tested clinically and have demonstrated beneficial effects. We review the results of experimental and clinical studies on donor or graft immunomodulation prior to transplantation and analyze the evidence to support clinical application of these strategies.

References

Jan 1, 1979·Scandinavian Journal of Thoracic and Cardiovascular Surgery·A Soots, P Häyry
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K KarmannJ S Pober
Apr 1, 1995·Seminars in Immunology·L L Lanier, J H Phillips
Jan 1, 1995·Annual Review of Medicine·J H Southard, F O Belzer
Aug 10, 1995·The New England Journal of Medicine·P I TerasakiS Takemoto
May 1, 1996·Biological Signals·Y K LeeA Y Liu
Aug 1, 1996·Journal of the American Society of Nephrology : JASN·M Epstein
Feb 1, 1997·Current Opinion in Immunology·R Medzhitov, C A Janeway
Sep 1, 1997·The Journal of Clinical Investigation·M TakadaN L Tilney
Sep 18, 1997·The Journal of Clinical Investigation·P Panina-BordignonF Sinigaglia
Nov 5, 1997·Transplantation·N L Tilney, R D Guttmann
Jan 1, 1998·Transplantation Proceedings·J H Southard
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Jan 16, 1999·Journal of the American Society of Nephrology : JASN·P F HalloranC Barth
Dec 10, 1999·The Journal of Clinical Investigation·F AmersiJ W Kupiec-Weglinski
Mar 17, 2000·Immunological Reviews·A Fox, L C Harrison
Jul 21, 2000·Annals of Surgery·J PratschkeN L Tilney
Dec 15, 2000·Kidney International·S P BergerF J Van Der Woude
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·L C Goldberg
May 5, 2001·Immunity·M Sykes
Aug 24, 2001·Cell Biology International·P VerbekeS I Rattan
Sep 8, 2001·Nature Immunology·M SchnareR Medzhitov

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Citations

Feb 28, 2008·Transplantation·Ruediger HoerbeltJoren C Madsen
Mar 19, 2008·Transplantation·Maarten Naesens, Minnie Sarwal
Sep 23, 2010·Transplantation·Katja KotschJohann Pratschke
Oct 28, 2009·Transplantation Proceedings·C ChamorroJ C Michelena
Jan 15, 2009·Transplant Immunology·J CarstensH E Hansen
Nov 16, 2013·Immunologic Research·Carmen FotinoAntonello Pileggi
May 31, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Jiang-Ming QianJian Wu
Dec 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Hui ChenZhiyuan Chen
Jun 15, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M M SarwalO Salvatierra
Jan 22, 2011·British Journal of Pharmacology·Shogo ShimizuKeisuke Satoh
May 6, 2015·International Urology and Nephrology·Xiaodong WengXiuheng Liu
Mar 13, 2014·Vascular Cell·Xinguo JiangMark R Nicolls
May 4, 2013·Transplantation Reviews·Timm HeinbokelStefan G Tullius
Nov 14, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Heiko M MundtPeter Schnülle
Apr 1, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Allyson Hart, Rachel E Patzer
Mar 6, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Qi ChengCarl Atkinson
May 4, 2017·Journal of the American Society of Nephrology : JASN·Nicholas A Zwang, Joseph R Leventhal
Dec 21, 2012·Current Opinion in Organ Transplantation·Naima SouidiMartina Seifert
Feb 29, 2020·World Journal of Transplantation·Julianna E BuchwaldPaulo N Martins
Jul 14, 2020·Frontiers in Immunology·Angus HannM Thamara P R Perera
Nov 26, 2015·Transplantation·Maarten Naesens
Oct 28, 2019·Transplantation·Christine G Yao, Paulo N Martins
Feb 12, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Paulo N MartinsPatricia Sheiner

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