Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver

Japanese Journal of Cancer Research : Gann
S WadaH Tsuda

Abstract

Modifying effects of fibrosis or a cirrhotic state, caused by treatment with swine serum (SS), on the induction of preneoplastic focal lesions were assessed in a rat medium-term liver bioassay model for the detection of environmental carcinogens, in which the test compound is administered during the promotion phase after initiation with diethylnitrosamine. In experiment I, repeated intraperitoneal administration of SS concomitantly with the hepatopromoting agent deoxycholic acid (DCA) or phenobarbital (PB) resulted in a cirrhotic state and a significant increase in the number or size of preneoplastic glutathione S-transferase placental form (GST-P)-positive liver cell foci as compared to the corresponding DCA or PB alone groups. In experiment II, SS was given prior to commencement of the same medium-term bioassay system, in which a known hepatopromoting agent, DCA, 17-alpha-ethynylestradiol, or 2-acetylaminofluorene, was applied. In this case, the liver did not show obvious cirrhotic change and, rather than any enhancement, slight inhibition of promotion occurred. The results indicate that a coexisting, but not a pre-existing, cirrhotic condition acts to increase growth pressure on GST-P+ preneoplastic foci, and suggest that co...Continue Reading

References

Jul 11, 1975·Biochimica Et Biophysica Acta·A B Pardee
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Bhunchet, K Wake
Mar 1, 1986·Acta Pathologica Japonica·M Nakano
Jan 1, 1974·Journal of Medical Primatology·C S Lieber, L M DeCarli
May 1, 1984·Seminars in Liver Disease·M C Kew, H Popper
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger

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Citations

Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I SakaidaK Okita
Sep 6, 2007·The Journal of Toxicological Sciences·Yohei MiyamotoMari Miyamoto

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