Modifying integra as a regeneration template in deep tissue planes

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
J D Frame, J E Frame

Abstract

Contour defects resulting in deformity caused by lack of tissue can be improved by conventional surgery using autologous tissue, but there is always a donor site morbidity. Integra has been available since the early 1980's for use in acute burns and more recently in reconstruction. It has been shown histologically to act as a tissue regeneration template. The regenerated dermis is buried under an autologous thin split-skin graft. In this study, the principle of burying Integra (without the silicone layer) has been applied to deep tissue defects in 12 reconstructive cases. Such regenerated tissues survive at least 3 years after burying. Modification to the technique to avoid visible edges are being developed.

References

Jun 23, 2001·Plastic and Reconstructive Surgery·N S MoiemenJ D Frame
Aug 17, 2001·Tissue Engineering·N O OjehH A Navsaria
Apr 3, 2004·Plastic and Reconstructive Surgery·James D FrameAndrew Burd

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Citations

Feb 9, 2007·Advances in Skin & Wound Care·Kevin WooR Gary Sibbald
Sep 3, 2010·Plastic and Reconstructive Surgery·Christopher D KnottsChristian A El Amm
Jan 29, 2014·Plastic and Reconstructive Surgery·Petros Konofaos, William L Hickerson
Apr 17, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Bassem M Mossaad, James D Frame
Oct 18, 2008·The American Journal of Emergency Medicine·Chris L MooreMichael R Osborne
Nov 6, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·J FaulhaberW Koenen

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