PMID: 9555540Apr 29, 1998Paper

Modifying the criteria of the American Joint Commission on Cancer staging system in melanoma

Current Opinion in Oncology
M I Ross

Abstract

The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and modifications are suggested based on a review of the recent literature: 1) for stage I and II patients, Clark's level of invasion is only predictive in patients with melanomas less than 1 mm, the best statistical fit for tumor thickness cutoffs are less than 1 mm, 1 to 2 mm, 2 to 4 mm, and greater than 4 mm, and ulceration should be included as part of the staging system; 2) in stage III patients, the presently used criteria of 3 cm in size needs to abandoned and replaced by the number of lymph nodes involved and the number of lymph node basins involved; and 3) local recurrence presenting as local metastases and satellite disease represent a biologic continuum of regional lymphatic dissemination and should both be classified in the stage III prognostic groups. These modifications, if accepted, should provide the ability to better stratify patients for future adjuvant therapy trials.

Citations

Jan 30, 2002·Journal of Surgical Oncology·William M MendenhallEdward M Copeland
Apr 7, 2006·Virchows Archiv : an International Journal of Pathology·Heike ImmervollAnders Molven
Dec 2, 2009·Breast Cancer Research and Treatment·Elena M KouriNancy L Keating
Feb 14, 2003·Current Oncology Reports·Chad A Zender, Guy J Petruzzelli
Jun 25, 2002·The Annals of Thoracic Surgery·James R HeadrickPeter C Pairolero
Oct 2, 2001·Pharmacology & Therapeutics·M LeszczynieckaP B Fisher
Apr 4, 2000·Oral Oncology·M J Hicks, C M Flaitz
Jun 4, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·O J O'ConnorH P Redmond
Feb 9, 2007·Annals of Surgical Oncology·Victoria SooEdward A Levine
Jun 8, 2001·Current Oncology Reports·L M Schuchter
Nov 30, 2010·Surgical Oncology Clinics of North America·Paxton V Dickson, Jeffrey E Gershenwald
Feb 17, 2009·Seminars in Oncology Nursing·Margot Roberts SweedSteven J Cohen
Oct 7, 2004·International Journal of Radiation Oncology, Biology, Physics·Gert De MeerleerWilfried De Neve
Apr 11, 2015·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Giuseppina ApicellaMarco Krengli
Feb 23, 2010·AJR. American Journal of Roentgenology·Swati D DeshmukhR Brooke Jeffrey
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio V ScagliottiValter Torri
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
Rafael Fuentes-RaspallGemma Oliu-Isern
International Journal of Radiation Oncology, Biology, Physics
James W DenhamCatherine D'Este
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Mark A SidhomKeen-Hun Tai
© 2022 Meta ULC. All rights reserved