Modifying the n-3 fatty acid content of the maternal diet to determine the requirements of the fetal and suckling rat

Lipids
Philippe GuesnetG Durand

Abstract

During perinatal development, docosahexaenoic acid (22:6n-3) accumulates extensively in membrane phospholipids of the nervous system. To evaluate the n-3 fatty acid requirements of fetal and suckling rats, we investigated the accumulation of 22:6n-3 in the brain and liver of pup rats from birth to day 14 postpartum when their dams received increasing amounts of dietary 18:3n-3 (from 5 to 800 mg/100 g diet) during the pregnancy-lactation period. The fatty acid composition of brain and liver phospholipids of pups, as well as that of dam's milk, was determined. At birth, 22:6n-3 increased regularly to reach the highest level when the maternal diet contained 800 mg 18:3n-3/100 g. On days 7 and 14 postpartum, brain 22:6n-3 plateaued at a maternal dietary supply of 200 mg/100 g. Docosapentaenoic acid (22:5n-6) had the opposite temporal pattern. The unusually high concentration of eicosapentaenoic acid (20:5n-3) in liver and dam's milk observed at the highest 18:3n-3 intake suggests an excessive dietary supply of this fatty acid. All these data suggest that the n-3 fatty acid requirements of the pregnant rat are around 400 mg 18:3n-3 and those of the lactating rat at 200 mg (i.e., 0.9 and 0.45% of dietary energy, respectively). The va...Continue Reading

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Citations

Apr 14, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B E Levin
Jun 18, 2002·Journal of Neurochemistry·Adriana Ximenes da SilvaMonique Lavialle
Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·N PerinA Thomson
May 15, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Salvador Garcia-CalatayudPablo Sanjurjo Crespo
Jul 26, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Géraldine MathieuSylvie Vancassel
Sep 2, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P GuesnetS C Cunnane
Sep 12, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sylvie Chalon
May 20, 2003·Journal of Lipid Research·Sabah AïdMonique Lavialle
Sep 18, 2002·Journal of Lipid Research·Cordula BlankRobert A Gibson
Apr 17, 2004·Journal of Neurochemistry·Ercem KodasSylvie Chalon
Apr 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Judith N GorskiBarry E Levin
Oct 27, 2006·Molecular and Cellular Biochemistry·Frantisek NovákOlga Nováková
Oct 3, 2003·The American Journal of Clinical Nutrition·Jean-Marc AlessandriPhilippe Guesnet

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