PMID: 16515467Mar 7, 2006Paper

Modifying toll-like receptor 9 signaling for therapeutic use

Mini Reviews in Medicinal Chemistry
Rabindra N Bhattacharjee, Shizuo Akira

Abstract

Toll-like receptor (TLR) 9 recognizes synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytidyl-deoxyguanosine (CpG) motifs and mimics the immunostimulatory activity of bacterial DNA. Both innate and adaptive immune systems are activated through TLR9 signaling and thus its synthetic agonists or inhibitors have potential significance as a target for therapeutic use in immunological disorders. Interestingly, TLR9 found in the dendritic cells and B cells produce differential outcome in response to structurally distinct CpG-ODNs. While one class of CpG-ODN activates B cells and produce immunoglobulin, other can either redirect plasmacytoid dendritic (pDC) cells to secrete high level of IFNalpha or myeloid dendritic cells (mDC) to produce Th1-like cytokines and chemokines necessary for asthma control. This review focuses on potential use of various synthetic CpG to modify TLR9 signaling for therapeutic treatment of multiple diseases including cancer, asthma, allergy and systemic lupus erythematosus (SLE).

Citations

Nov 21, 2007·Journal of Clinical Immunology·Shee Eun LeeJoon Haeng Rhee
Oct 10, 2009·Current Allergy and Asthma Reports·Vesselin V DimovThomas B Casale
Feb 19, 2008·Cardiovascular Research·Toshiyuki Takahashi
May 5, 2012·International Archives of Allergy and Immunology·D von BubnoffT Bieber
Feb 21, 2008·World Journal of Gastroenterology : WJG·Shugui WangYuan Kun Lee
Feb 14, 2008·The Journal of Allergy and Clinical Immunology·Thomas B Casale, Jeffrey R Stokes
Jun 16, 2006·Journal of the American Society of Nephrology : JASN·Peter G Tipping
Apr 27, 2007·Journal of the American Society of Nephrology : JASN·Rahul D PawarHans-Joachim Anders
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hua ShenDaniel R Goldstein

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