Modifying toxicokinetics with antidotes

Toxicology Letters
Frédéric J BaudC Bismuth

Abstract

Five approaches may be described through which antidotes can modify toxicokinetics: (1) Decreased bioavailability of the toxins; (2) Cellular redistribution of the toxin in the organism; (3) Promotion of elimination in an unchanged form; (4) Slowing of metabolic activation pathways; (5) Acceleration of metabolic deactivation pathways. However, the ability to modify toxicokinetics with a new treatment, while demonstrating an understanding of the mechanism of action, must never be construed to be, in and of itself, the goal of therapy. The ultimate evaluation of an antidote modifying toxicokinetics is strictly clinical.

References

Dec 19, 1991·The New England Journal of Medicine·F J BaudC Bismuth
Jul 14, 1988·The New England Journal of Medicine·F J BaudC Bismuth
Nov 1, 1987·Toxicology and Applied Pharmacology·R A Yokel, H B Kostenbauder
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·K O LindrosM Salaspuro
Sep 9, 1982·The New England Journal of Medicine·M J BergG F Johnson
Mar 9, 1995·The New England Journal of Medicine·F J BaudJ M Scherrmann

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Citations

Dec 3, 2014·Emergency Medicine Clinics of North America·Stephen W Borron, Vikhyat S Bebarta
Nov 8, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Stephen W Borron
May 20, 2008·Expert Opinion on Drug Metabolism & Toxicology·Bruno MégarbaneFrédéric J Baud
Oct 10, 2007·Clinical Pharmacokinetics·Darren M Roberts, Nick A Buckley
Jan 15, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Deborah E KeilMargie M Peden-Adams

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