Modular AND Gate-Controlled Delivery Platform for Tumor Microenvironment Specific Activation of Protein Activity

Chemistry : a European Journal
Enguo JuXiaogang Qu

Abstract

Protein therapeutics have inspired intensive research interest in a variety of realms. It is still urgently required to avoid premature or unexpected activation of therapeutic proteins to achieve great specificity for therapy. Herein, we reported a modular AND gate-controlled delivery platform for tumor microenvironment specific activation of therapeutic protein activity based on biomineralization of molecular glue-adhered protein enzyme. The AND gate integrates the specific microenvironment of tumor tissues (acidic pH and a certain concentration of ATP) as inputs and activates the therapeutic activity of protein only when both inputs are active. More importantly, the activity of therapeutic protein would not be activated either at acidic pH or in the presence of ATP, which could greatly avoid the deleterious effect on normal tissues. Besides, this AND gate can be modular design and suitable for a variety of therapeutic proteins and nucleic acids.

References

May 12, 2005·Journal of the American Chemical Society·Milan N StojanovicDarko Stefanovic
Dec 23, 2006·Clinical Chemistry·Mark W GormanCharles W Buffington
Mar 7, 2008·Journal of the American Chemical Society·Guinevere StrackEvgeny Katz
Nov 26, 2010·Nature Medicine·Konrad WilhelmRobert Zeiser
Jan 11, 2011·Journal of the American Chemical Society·Chun-Ling ZhuXiao-Ru Wang
May 14, 2011·Chemical Society Reviews·Zhen GuYi Tang
Jul 26, 2011·Chemistry : a European Journal·Fang PuXiaogang Qu
Sep 25, 2012·Angewandte Chemie·Guangchuan WangRuikang Tang
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guangchuan WangCheng-Feng Qin
May 22, 2013·Journal of the American Chemical Society·Stefanie KohseUdo Kragl
Mar 13, 2014·Nature Communications·Ran MoZhen Gu
Nov 2, 2014·Journal of the American Chemical Society·Mingxu YouWeihong Tan
Apr 30, 2015·Journal of the American Chemical Society·Jing TianXiaogang Liu
Sep 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jinzhi DuShuming Nie
Dec 10, 2015·Journal of the American Chemical Society·P K HashimTakuzo Aida
Jan 8, 2016·Journal of the American Chemical Society·Tian TianXiang Zhou
Apr 19, 2016·Journal of the American Chemical Society·Kou OkuroTakuzo Aida
Oct 17, 2017·Chemical Society Reviews·Rina MogakiTakuzo Aida
Sep 28, 2018·Advanced Healthcare Materials·Xiaowen LiuZhuang Liu

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