Modular integration of electronics and microfluidic systems using flexible printed circuit boards

Lab on a Chip
Amy WuBernhard Boser

Abstract

Microfluidic systems offer an attractive alternative to conventional wet chemical methods with benefits including reduced sample and reagent volumes, shorter reaction times, high-throughput, automation, and low cost. However, most present microfluidic systems rely on external means to analyze reaction products. This substantially adds to the size, complexity, and cost of the overall system. Electronic detection based on sub-millimetre size integrated circuits (ICs) has been demonstrated for a wide range of targets including nucleic and amino acids, but deployment of this technology to date has been limited due to the lack of a flexible process to integrate these chips within microfluidic devices. This paper presents a modular and inexpensive process to integrate ICs with microfluidic systems based on standard printed circuit board (PCB) technology to assemble the independently designed microfluidic and electronic components. The integrated system can accommodate multiple chips of different sizes bonded to glass or PDMS microfluidic systems. Since IC chips and flex PCB manufacturing and assembly are industry standards with low cost, the integrated system is economical for both laboratory and point-of-care settings.

References

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Citations

Feb 16, 2013·Chemical Reviews·Pamela N NgeAdam T Woolley
Mar 13, 2013·Lab on a Chip·Ahmad Ahsan NawazTony Jun Huang
Sep 22, 2012·Journal of Chromatography. a·Pamela N NgeAdam T Woolley
Aug 2, 2016·Biosensors & Bioelectronics·Despina MoschouThemistoklis Prodromakis
Jun 13, 2013·Journal of Laboratory Automation·M Kursad ArazAmy E Herr
Mar 16, 2017·Lab on a Chip·Despina Moschou, Angeliki Tserepi
Feb 28, 2018·Advanced Materials·Sherjeel M KhanMuhammad M Hussain
Sep 30, 2010·Lab on a Chip·Shi Cheng, Zhigang Wu
Apr 1, 2014·Lab on a Chip·Timir Datta-ChaudhuriElisabeth Smela
Mar 25, 2011·Lab on a Chip·Holger Becker
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Mehdi SahmaniMehdi Azad
Oct 12, 2018·Sensors·Joni KilpijärviAnita Lloyd Spetz

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