Dec 22, 2006

Modularity and intrinsic evolvability of Hsp90-buffered change

PloS One
Charles C CareySuzannah Rutherford


Hsp90 controls dramatic phenotypic transitions in a wide array of morphological features of many organisms. The genetic-background dependence of specific abnormalities and their response to laboratory selection suggested Hsp90 could be an 'evolutionary capacitor', allowing developmental variation to accumulate as neutral alleles under normal conditions and manifest selectable morphological differences during environmental stress. The relevance of Hsp90-buffered variation for evolution has been most often challenged by the idea that large morphological changes controlled by Hsp90 are unconditionally deleterious. To address this issue, we tested an Hsp90-buffered abnormality in Drosophila for unselected pleiotropic effects and correlated fitness costs. Up to 120-fold differences in penetrance among six highly related selection lines, started from an initially small number of flies and rapidly selected for and against a deformed eye trait (dfe), did not translate into measurable differences in any of several tests of viability, lifespan or competitive fitness. Nor were 17 dfe Quantitative Trait Loci (QTL) associated with fitness effects in over 1,400 recombinant lines. Our ability to detect measurable effects of inbreeding, media ...Continue Reading

  • References18
  • Citations9


  • References18
  • Citations9


Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Genes, Insect
Biochemical Pathway
Quantitative Trait Loci
Laboratory Procedures
CFC1 gene

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