Modularity of endpoint force patterns evoked using intraspinal microstimulation in treadmill trained and/or neurotrophin-treated chronic spinal cats.

Journal of Neurophysiology
Vanessa S Boyce, M A Lemay

Abstract

Chronic spinal cats with neurotrophin-secreting fibroblasts (NTF) transplants recover locomotor function. To ascertain possible mechanisms, intraspinal microstimulation was used to examine the lumbar spinal cord motor output of four groups of chronic spinal cats: untrained cats with unmodified-fibroblasts graft (Op-control) or NTF graft and locomotor-trained cats with unmodified-fibroblasts graft (Trained) or NTF graft (Combination). Forces generated via intraspinal microstimulation at different hindlimb positions were recorded and interpolated, generating representations of force patterns at the paw. Electromyographs (EMGs) of hindlimb muscles, medial gastrocnemius, tibialis anterior, vastus lateralis, and biceps femoris posterior, were also collected to examine relationships between activated muscles and force pattern types. The same four force pattern types obtained in spinal-intact cats were found in chronic spinal cats. Proportions of force patterns in spinal cats differed significantly from those in intact cats, but no significant differences in proportions were observed among individual spinal groups (Op-control, NTF, Trained, and Combination). However, the proportions of force patterns differed significantly between tra...Continue Reading

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Citations

Mar 28, 2013·Annals of the New York Academy of Sciences·Simon F Giszter, Corey B Hart
Dec 13, 2012·IEEE Reviews in Biomedical Engineering·Dario Farina, Francesco Negro
Jun 6, 2009·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Michel A LemayWarren M Grill
Jun 6, 2014·Journal of Neurophysiology·Alexander N KlishkoBoris I Prilutsky
Jul 1, 2021·Journal of Neurophysiology·Alexander N KlishkoBoris I Prilutsky

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