Modulating auditory selective attention by non-invasive brain stimulation: Differential effects of transcutaneous vagal nerve stimulation and transcranial random noise stimulation

The European Journal of Neuroscience
Katharina S RufenerTino Zaehle

Abstract

Selective attention is a basic process required to maintain goal-directed behavior by appropriately responding to target stimuli and suppressing reactions to non-target stimuli. It has been proposed that auditory selective attention is linked to the activity of the locus coeruleus-norepinergic (LC-NE) system and a large-scale fronto-parietal cortical network, but there is still sparse causal evidence for these assumptions. By applying transcutaneous vagal nerve stimulation (tVNS) and transcranial random noise stimulation (tRNS) over the frontal cortex, we systematically assessed the involvement of these subcortical and cortical components in the regulation of auditory selective attention. Using a single-blinded, sham-controlled, within-subject design we analyzed online effects of tVNS and tRNS in 20 healthy participants during an auditory oddball paradigm. We show significant stimulation-dependent modulations of auditory selective attention on the behavioral and electrophysiological level. Compared to sham, tVNS increased the P3 amplitude, while tRNS reduced the reaction time to target stimuli. Moreover, both techniques reduced the P3 latency. Our data provide evidence for the functional relevance of the subcortical NE system i...Continue Reading

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Citations

Jan 4, 2020·The International Journal of Neuropsychopharmacology·Stevan NikolinColleen K Loo
Nov 26, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Ruth KlamingImanuel Lerman
Dec 23, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Yu WangPeijing Rong
May 29, 2021·Harvard Review of Psychiatry·Chinedu I AnyaejiDavid Silbersweig

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