Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis

International Journal of Molecular Sciences
Yu-Hsuan LaiHelen H W Chen

Abstract

Platinum (Pt)-based antitumor agents have been effective in treating many human malignancies. Drug importing, intracellular shuffling, and exporting-carried out by the high-affinity copper (Cu) transporter (hCtr1), Cu chaperone (Ato x1), and Cu exporters (ATP7A and ATP7B), respectively-cumulatively contribute to the chemosensitivity of Pt drugs including cisplatin and carboplatin, but not oxaliplatin. This entire system can also handle Pt drugs via interactions between Pt and the thiol-containing amino acid residues in these proteins; the interactions are strongly influenced by cellular redox regulators such as glutathione. hCtr1 expression is induced by acute Cu deprivation, and the induction is regulated by the transcription factor specific protein 1 (Sp1) which by itself is also regulated by Cu concentration variations. Copper displaces zinc (Zn) coordination at the zinc finger (ZF) domains of Sp1 and inactivates its DNA binding, whereas Cu deprivation enhances Sp1-DNA interactions and increases Sp1 expression, which in turn upregulates hCtr1. Because of the shared transport system, chemosensitivity of Pt drugs can be modulated by targeting Cu transporters. A Cu-lowering agent (trientine) in combination with a Pt drug (carbo...Continue Reading

References

Nov 1, 1992·Trends in Biochemical Sciences·T Ishikawa
Jul 1, 1988·Molecular and Cellular Biology·D J Thiele
Jun 1, 1993·British Journal of Cancer·D P Gately, S B Howell
Aug 31, 2000·Nature Structural Biology·A K WernimontA C Rosenzweig
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiko IshidaIra Herskowitz
Oct 16, 2002·Structure·Fabio ArnesanoAndrew R Thompsett
Jan 16, 2003·Nucleic Acids Research·S Sri KrishnaNick V Grishin
Jan 24, 2003·Journal of Bioenergetics and Biomembranes·Diane W Cox, Steven D P Moore
Jul 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Goli SamimiStephen B Howell
Nov 9, 2004·Biochemical and Biophysical Research Communications·Valérie TanchouEric Quéméneur
Dec 21, 2004·Critical Reviews in Oncology/hematology·Roohangiz Safaei, Stephen B Howell
Aug 2, 2005·Neuro-oncology·Steven BremUNKNOWN New Approaches to Brain Tumor Therapy CNS Consortium
Nov 10, 2005·Eukaryotic Cell·Greg KellerDennis R Winge
Feb 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephen G Aller, Vinzenz M Unger
Aug 25, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Maria FranziniFranco Zunino
Feb 24, 2007·Cancer Metastasis Reviews·Macus Tien KuoToshihisa Ishikawa
Mar 6, 2007·Critical Reviews in Oncology/hematology·David J Stewart
Jul 7, 2007·Physiological Reviews·Svetlana LutsenkoOleg Y Dmitriev
Jul 13, 2007·Nature Reviews. Cancer·Lloyd Kelland
Oct 17, 2007·Annual Review of Pharmacology and Toxicology·Matthew D HallMichael M Gottesman
Feb 5, 2008·The Journal of Biological Chemistry·Shinichi ItohTohru Fukai
Mar 28, 2008·Biochemical and Biophysical Research Communications·Inken Wierstra
Mar 28, 2008·Bioinorganic Chemistry and Applications·Suree NarindrasorasakBibudhendra Sarkar
Apr 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Manuel González-Guerrero, José M Argüello
Aug 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Faiza HussainPernilla Wittung-Stafshede
Sep 9, 2008·Cancer Treatment Reviews·Anshul Gupte, Russell J Mumper
Nov 11, 2008·Cancer Chemotherapy and Pharmacology·Cara A RabikM Eileen Dolan
Jan 7, 2009·Journal of Inorganic Biochemistry·Roohangiz SafaeiStephen B Howell
Jan 15, 2009·The Journal of Biological Chemistry·Karoline LeonhardtDominik Huster
Mar 20, 2009·International Journal of Cancer. Journal International Du Cancer·Eva Martinez-BalibreaAlbert Abad
Jul 16, 2009·Current Medicinal Chemistry·Giacomo CossaPaola Perego
Sep 11, 2009·The Journal of Biological Chemistry·Shannon A Molloy, Jack H Kaplan
Oct 8, 2009·Journal of the American Chemical Society·Amie K Boal, Amy C Rosenzweig

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Citations

Dec 6, 2018·International Journal of Molecular Sciences·Christina N Banti, Sotiris K Hadjikakou
Feb 11, 2020·Frontiers in Oncology·Cecilie AbildgaardSilvia R Rogatto
Aug 28, 2019·International Journal of Molecular Sciences·Shang-Hung Chen, Jang-Yang Chang
Jan 22, 2021·Seminars in Cancer Biology·Alia GhoneumNeveen Said
Jun 23, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·David LukanovićKatarina Černe
Nov 28, 2020·Current Topics in Medicinal Chemistry·Tiziano Marzo, Diego La Mendola
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger
Aug 18, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Andreia ValentePetra Heffeter
Jul 10, 2019·Journal of the American Chemical Society·Alessia LasorsaFabio Arnesano

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Methods Mentioned

BETA
protein folding
transfection
biopsies

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