Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route.

Drug Delivery and Translational Research
Natália N FerreiraMaria Palmira D Gremião

Abstract

Nose-to-brain delivery is a promising approach to target drugs into the brain, avoiding the blood-brain barrier and other drawbacks related to systemic absorption, and enabling an effective and safer treatment of diseases such as glioblastoma (GBM). Innovative materials and technologies that improve residence time in the nasal cavity and modulate biological interactions represent a great advance in this field. Mucoadhesive nanoparticles (NPs) based on poly(lactic-co-glycolic acid) (PLGA) and oligomeric chitosan (OCS) were designed as a rational strategy and potential platform to co-deliver alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) into the brain, by nasal administration. The influence of formulation and process variables (O/Aq volume ratio, Pluronic concentration, PLGA concentration, and sonication time) on the properties of CHC-loaded NPs (size, zeta potential, PDI and entrapment efficiency) was investigated by a two-level full factorial design (24). Round, stable nano-sized particles (213-875 nm) with high positive surface charge (+ 33.2 to + 58.9 mV) and entrapment efficiency (75.69 to 93.23%) were produced by the emulsification/evaporation technique. Optimal process conditions were...Continue Reading

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Citations

Mar 9, 2021·Neurochemistry International·Mukta AgrawalAmit Alexander
May 21, 2021·International Journal of Pharmaceutics·Natália N FerreiraMaria Palmira D Gremião
Jun 7, 2021·International Journal of Pharmaceutics·Marcela Tavares LuizMarlus Chorilli
Oct 15, 2020·Carbohydrate Polymers·Leonardo M B FerreiraMaria Palmira D Gremião

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Methods Mentioned

BETA
X-ray
scanning electron microscopy

Software Mentioned

GraphPad
ImageJ
GraphPad Prism
ImageJ®
STATISTICA

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