Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

Pharmacological Reviews
Annika H RunegaardUlrik Gether

Abstract

For more than 60 years, dopamine (DA) has been known as a critical modulatory neurotransmitter regulating locomotion, reward-based motivation, and endocrine functions. Disturbances in DA signaling have been linked to an array of different neurologic and psychiatric disorders, including Parkinson's disease, schizophrenia, and addiction, but the underlying pathologic mechanisms have never been fully elucidated. One major obstacle limiting interpretation of standard pharmacological and transgenic interventions is the complexity of the DA system, which only appears to widen as research progresses. Nonetheless, development of new genetic tools, such as chemogenetics, has led to an entirely new era for functional studies of neuronal signaling. By exploiting receptors that are engineered to respond selectively to an otherwise inert ligand, so-called Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), chemogenetics enables pharmacological remote control of neuronal activity. Here we review the recent, extensive application of this technique to the DA field and how its use has advanced the study of the DA system and contributed to our general understanding of DA signaling and related behaviors. Moreover, we discuss the...Continue Reading

References

Jan 1, 1976·European Journal of Pharmacology·A J PijnenburgJ M Van Rossum
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·M S HooksJ B Justice
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·J M DeminiereH Simon
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Oct 6, 1997·Science·G F Koob, M Le Moal
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·S R JonesM G Caron
Sep 2, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·W H ChangM W Jann
Jan 16, 1999·Molecular and Cellular Neurosciences·E V KuzhikandathilG S Oxford
Sep 26, 2002·The Journal of Biological Chemistry·Natalie LavineHubert H M Van Tol
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Niklas LindgrenGilberto Fisone
Dec 15, 1958·Acta Physiologica Scandinavica·A CARLSSON, B WALDECK
Dec 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaret E BalfourLique M Coolen
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nao ChuhmaStephen Rayport
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jean-Martin BeaulieuMarc G Caron
Sep 29, 2004·Genesis : the Journal of Genetics and Development·Jonas LindebergTed Ebendal
Nov 4, 2004·Journal of Receptor and Signal Transduction Research·Kim A NeveHeather Trantham-Davidson
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph M SavittTed M Dawson
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thomas S HnaskoRichard D Palmiter
Jul 26, 2006·Genesis : the Journal of Genetics and Development·Cristina M BäckmanAndreas C Tomac
Jan 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Martin BeaulieuMarc G Caron
Mar 3, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Toru KobayashiKazutaka Ikeda
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Blaine N ArmbrusterBryan L Roth
Apr 6, 2007·Trends in Neurosciences·Anders Björklund, Stephen B Dunnett
Apr 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marc WelterEmiliana Borrelli
May 19, 2007·Current Opinion in Neurobiology·Gonzalo E Torres, Susan G Amara
Jun 30, 2007·Annual Review of Neuroscience·Wolfram Schultz
Nov 14, 2007·Archives of Neurology·Nora D VolkowFrank Telang
Mar 4, 2008·British Journal of Pharmacology·V VengelieneR Spanagel
Aug 1, 2008·Nature Methods·Bruce R ConklinBryan L Roth
Apr 22, 2009·Learning & Memory·Jamie PetersGregory J Quirk

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Citations

Jun 23, 2019·Journal of Neuroscience Research·Chiara CiriachiMattias Rickhag
Apr 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Di WuHiroki Yokota
Sep 19, 2020·PloS One·Raphaël GoutaudierSebastien Carnicella
Jul 29, 2020·Frontiers in Molecular Neuroscience·Juan-Carlos CerpaEtienne Coutureau
Jul 19, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fernanda Leite, Laura Ribeiro
Apr 9, 2020·Scientific Reports·Jongwook ChoHyoung-Ihl Kim
Jan 27, 2021·Trends in Pharmacological Sciences·Graeme MilliganAndrew B Tobin
Jan 23, 2021·Neuropharmacology·R MaldonadoE Martín-García
Feb 20, 2021·Translational Psychiatry·Alexios-Fotios A MentisGeorge P Chrousos
Nov 3, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Agata Casado-SainzMikael Palner

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