Modulating effect of a hydroxychalcone and a novel coumarin-chalcone hybrid against mitomycin-induced genotoxicity in somatic cells of Drosophila melanogaster

Drug and Chemical Toxicology
Jefferson Hollanda VérasL Chen-Chen

Abstract

Chalcones are aromatic compounds found in plants or obtained by synthetic methods. These compounds and their derivatives have been proven to be responsible for a variety of pharmacological properties, including anti-inflammatory and anticancer activities. A second interesting class of compound are coumarins which comprises a large class of molecules derived from phenolic compounds found mainly in plants, exhibiting multiple biological activities such as antioxidant and anti-tumoral properties. Due to the relevance of these compounds, this study aimed to investigate the genotoxic/antigenotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one (2HMC) and the coumarin-chalcone hybrid [7-methoxy-3-(E)-3-(3,4,5-trimethoxyphenyl)acryloyl-2H-cromen-2-one] (4-MET) using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. To assess the mutagenic and recombinogenic activities, larvae derived from standard and high bioactivation crosses were treated with different concentrations of 2HMC (10, 50, 100 and 400 µg/mL) or 4-MET (5, 50, 100 and 400 µg/mL) for 48 h. Dimethylsulfoxide (DMSO, 0.5%) was the negative control group. The anti-recombinogenic and antimutagenic activities were ...Continue Reading

References

Jan 11, 1992·Environmental and Molecular Mutagenesis·D L Morris, J B Ward
May 1, 1970·Mutation Research·M A Kastenbaum, K O Bowman
May 16, 1983·Biochemical and Biophysical Research Communications·T TorigoeH B Maruyama
Jan 1, 1984·Environmental Mutagenesis·U GrafP G Kale
Dec 1, 1995·Mutation Research·K Müller-TegethoffL Müller
Dec 8, 2004·Current Pharmaceutical Design·Konstantina C FylaktakidouDemetrios N Nicolaides
Jun 16, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Som D SharmaRakesh K Sharma
Jan 27, 2007·The Journal of Physical Chemistry. a·David KozlowskiJean-Luc Duroux
Nov 15, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Annalisa EventiGino Turchi
Jan 6, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yasir Hasan Siddique, Mohammad Afzal
Feb 24, 2009·Bioorganic & Medicinal Chemistry Letters·Thanh-Dao TranKhac-Minh Thai
Jun 23, 2009·Survey of Ophthalmology·Miguel A TeusJorge L Alió
Mar 23, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Zovko KoncićK Karlović
Nov 13, 2010·Bioorganic & Medicinal Chemistry Letters·Koneni V SashidharaSudhir Sinha
Jun 8, 2011·Mutation Research·Erico R CarmonaRicard Marcos
Oct 5, 2011·Oxidative Medicine and Cellular Longevity·B PoljsakI Ostan
Dec 7, 2011·Mutation Research·Simone ThoméRafael Rodrigues Dihl
Jan 10, 2013·Toxicology and Industrial Health·Mehmet GürbüzelHalit Kizilet
May 2, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·N Raghav, S Garg
Oct 4, 2014·Bioorganic & Medicinal Chemistry Letters·Sreeparna DasNaznin Ara Begum
Jan 13, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert R Maronpot
Apr 8, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P C OrsolinJ C Nepomuceno
Aug 4, 2016·European Journal of Medicinal Chemistry·Mohd Zaheen HassanMohamed Jawed Ahsan
Aug 5, 2016·Mini Reviews in Medicinal Chemistry·Devulapally SrikrishnaPramod Kumar Dubey
Aug 26, 2016·Genetics and Molecular Biology·Robson Alves da SilvaMauricio Lehmann
Dec 29, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mirley Alves VasconcelosMário Antônio Spanó
Mar 23, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Komal Panchal, Anand K Tiwari
Jun 3, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Victor Constante OliveiraMário Antônio Spanó
Jul 6, 2017·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Aroldo Vieira de Moraes FilhoLee Chen-Chen
Jan 3, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maria Paula Carvalho NavesAlexandre Azenha Alves de Rezende

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Citations

Dec 30, 2020·Journal of Toxicology and Environmental Health. Part a·A V D Melo BisnetoL Chen-Chen
Jun 29, 2021·Journal of Toxicology and Environmental Health. Part a·Thaís Teixeira da SilvaFrancielle Alline Martins

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