Modulating effect of lipid bilayer-carotenoid interactions on the property of liposome encapsulation

Colloids and Surfaces. B, Biointerfaces
Shuqin XiaFang Qin

Abstract

Liposomes have become an attractive alternative to encapsulate carotenoids to improve their solubility, stability and bioavailability. The interaction mechanism of carotenoid with lipid bilayer is one of the major concerns in improving the delivery efficiency of liposomes. In this study, the microstructure and carotenoid encapsulation efficiency of liposomes composed of native phospholipid (egg yolk phosphatidylcholine, EYPC) and nonionic surfactant Tween 80 were investigated by atomic force microscopy, dynamic light scattering, and Raman spectroscopy, respectively. Subsequently, the effects of carotenoid incorporation on the physical properties of liposomal membrane were performed by Raman spectroscopy, fluorescence polarization, and electron paramagnetic resonance. Results showed that the incorporation of carotenoids affected the liposomes morphology, size and size distribution to various extents. Analysis on the Raman characteristic peaks of carotenoids revealed that lutein exhibited the strongest incorporating ability into liposomes, followed by β-carotene, lycopene, and canthaxanthin. Furthermore, it was demonstrated that carotenoids modulated the dynamics, structure and hydrophobicity of liposomal membrane, highly dependi...Continue Reading

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Citations

Sep 19, 2018·The Journal of Experimental Biology·Carlos Alonso-AlvarezRafael Mateo
Feb 2, 2019·Drug Metabolism and Personalized Therapy·Mehran Alavi, Mehrdad Hamidi
Sep 12, 2019·International Journal of Molecular Sciences·Marta Salvador-CastellPhilippe M Oger
Sep 20, 2018·Journal of Food Science and Technology·Priscilla Pereira Dos SantosAlessandro de Oliveira Rios
Jan 6, 2021·Critical Reviews in Food Science and Nutrition·Saeid MaghsoudiThomas J Webster
Mar 6, 2021·Comprehensive Reviews in Food Science and Food Safety·Kizhakkeppurath Kumaran AjeeshkumarSoottawat Benjakul
Jun 15, 2021·Chemical Science·Xue WangGuangyan Qing
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mahdi MirahmadiFarzin Hadizadeh
May 31, 2018·Journal of Agricultural and Food Chemistry·Ling ChenFang Zhong
May 23, 2018·Journal of Agricultural and Food Chemistry·Marcelo P BarrosLorenzo Zacarias
Mar 30, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohamed MashalJose Luis Pedraz

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