Modulating Effect of the -158 γ (C→T) Xmn1 Polymorphism in Indian Sickle Cell Patients.

Mediterranean Journal of Hematology and Infectious Diseases
Sanjay PandeyRenu Saxena

Abstract

Xmn1 polymorphism is a known factor, which increases fetal haemoglobin production. Among the inherited disorders of blood, thalassaemia and Sickle Cell Diseases contributes to a major bulk of genetic diseases in India. Our aim was to verify the role of the Xmn1 polymorphism as a modulating factor in sickle cell patients and frequency of the polymorphism in Indian sickle cell patients. 60 sickle homozygous and 75 sickle beta thalassemia patients were included and 5 ml blood sample was collected from them. Screening of sickle patients was done by HPLC. An automated cell analyzer SYSMEX (K-4500 Model) was used to analyze the Complete Blood Count of patients. Xmn1 polymorphism analysis was done by PCR-RFLP and one-way ANOVA test was applied to analysis of variance between groups. Among the sickle patients 27 were heterozygous (+/-) and 19 were homozygous (+/+) while 30 were heterozygous (+/-) and 24 were homozygous (+/+) in sickle β-thalassemia patients. Extremely significant differences (p-value <0.001) of hematological parameters seen among patients with Xmn1 carrier and without the Xmn1 carrier. In our cases the clinical symptoms were barely visible and higher HbF level with Xmn1 carriers were found. Presence of Xmn1 polymorphis...Continue Reading

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Citations

May 10, 2017·Omics : a Journal of Integrative Biology·Alexandra KolliopoulouGeorge P Patrinos
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Wai Cheng FoongVip Viprakasit
Sep 15, 2018·International Journal of Laboratory Hematology·Nasir Al-AllawiChristian Oberkanins
Nov 17, 2017·British Journal of Haematology·Alireza Paikari, Vivien A Sheehan

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