Modulating effects of prostaglandins on parasympathetic-mediated secretory activities of rat salivary glands

Prostaglandins
J H Yu

Abstract

Exogenously administered PGE1 or PGE2, like atropine, markedly decreased both the flow and calcium concentration of parasympathetically evoked rat parotid saliva; PGF2 alpha was less effective. Despite the fact that prostaglandins greatly reduced the Ca concentration of nerve-evoked saliva, they did not change the glandular Ca concentration of either control or parasympathetically stimulated parotid glands. Prostaglandins (20 micrograms/kg, i.a.) decreased the Na or K concentration of nerve-evoked parotid saliva, but at lower doses had no significant effect. PGE1, PGE2, PGF2 alpha or atropine markedly decreased flow rates of similarly evoked rat submandibular saliva. Prostaglandins and atropine, however, decreased the Na concentration and increased the K concentration of parasympathetically evoked submandibular saliva. PGF2 alpha, like atropine, increased the Ca concentration of such saliva. Drug vehicle, ethanol, slightly decreased the flow of both parotid and submandibular saliva but not the ion secretion, Endogenous prostaglandins themselves may not play a role in secretory activities during parasympathetic nerve stimulation of rat salivary glands, since administration of indomethacin, and inhibitor of prostaglandin biosynth...Continue Reading

References

Dec 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·C A Schneyer
Apr 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·A Wennmalm, P Hedqvist
Sep 15, 1982·Experientia·J H YuC A Schneyer

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Citations

May 13, 2006·Neuroimmunomodulation·Carolina de la CalJuan Carlos Elverdín
Jan 1, 1990·Archives of Oral Biology·J H Yu, R S Redman
Mar 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S M Abdel-HakimS Q Alam
Dec 19, 2012·International Journal of Pediatric Otorhinolaryngology·F AbbasM El-Sharnouby
May 21, 2013·Archives of Oral Biology·J P PrestifilippoJ Fernandez-Solari
Mar 28, 2001·Annals of the New York Academy of Sciences·V RettoriS M McCann
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·A LomnicziJ C Elverdin

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