Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus.

Immunotherapy
Mohammad W KhanMansour Mohamadzadeh

Abstract

To investigate the mechanism(s) by which the intestinal commensal microbe Lactobacillus acidophilus can affect host immunity, we studied the role of a component of the cell wall, lipoteichoic acid, in colitis. Colitis was induced by the intraperitoneal injection of pathogenic CD4(+)CD25(-)CD45RB(hi) T cells into Rag1(-/-) mice. The parental strain, NCK56, or the lipoteichoic acid-deficient strain, NCK2025, was then administered orally. Fluorescent microscopy was employed to examine resulting cell populations and their cytokine production in the colon. NCK2025 enhanced IL-10 production by dendritic cells and macrophages. Increased numbers of regulatory dendritic cells coincided with the induction of activated FoxP3(+) Tregs. These results suggest that the oral administration of the genetically modified strain NCK2025 may be an effective immunotherapeutic approach that reprograms the immune response in colonic inflammatory conditions.

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Citations

Aug 22, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jennifer L Owen, Mansour Mohamadzadeh
Jul 24, 2013·Microbial Cell Factories·Rebeca MartínLuis G Bermúdez-Humarán
Apr 23, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sandra M Quezada, Raymond K Cross
Mar 15, 2013·Trends in Immunology·Peter van BaarlenMichiel Kleerebezem
Feb 11, 2015·Journal of Medical Microbiology·Behrooz Mozaffari naminMohammad Mehdi Soltan Dallal
Dec 21, 2016·Journal of Cellular Physiology·Seyed-Alireza EsmaeiliMaryam Rastin
Feb 5, 2019·Veterinary Immunology and Immunopathology·Sarah RaabisLaura Cersosimo

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Methods Mentioned

BETA
Confocal microscopy

Software Mentioned

TissueGnostics
ImageJ

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