PMID: 9524733Apr 3, 1998Paper

Modulating mechanisms of neuroendocrine cell activity: the LHRH pulse generator

Cellular and Molecular Neurobiology
F J LópezA Negro-Vilar

Abstract

1. Luteinizing hormone-releasing hormone (LHRH), synthesized in specialized neurons in the hypothalamus, is the prime regulator of reproduction. In its absence, reproductive development is arrested and disorders of LHRH secretion result in several reproductive dysfunctions. 2. The LHRH neuronal network plays a paramount role in the regulatory loop controlling gonadal homeostasis. LHRH input to the pituitary gland maintains gonadotropin secretion, which, in turn, is responsible for gonadal trophism. Steroidal and peptidergic hormones from the gonad close the regulatory system by establishing negative (male and females) and positive (females) feedback loops. 3. Interestingly, LHRH input to the pituitary is intermittent rather than continuous. In fact, continuous exposure to LHRH results in paradoxical hypogonadism. Several studies in animals have provided direct evidence for episodic secretion of LHRH into the hypophyseal portal system. However, the nature of the system(s) responsible for the generation of the LHRH pulsatile profile is not currently known. The recent observation that immortalized LHRH neurons secrete LHRH in a pulsatile manner suggests that the pulse generating mechanism resides within the LHRH neuronal network. ...Continue Reading

Citations

Jun 7, 2003·The Journal of Biological Chemistry·Hui SunLi Zhang
Jul 25, 2009·The Journal of Pharmacology and Experimental Therapeutics·Tsung-Tair Yang, Su-Jane Wang
Feb 24, 2012·The Journal of Pharmacology and Experimental Therapeutics·Cheng-Wei LuSu-Jane Wang
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Aug 22, 2003·The Journal of Biological Chemistry·János PolgárGuy L Reed
Nov 25, 2003·Alcoholism, Clinical and Experimental Research·Douglas P Dohrman And, Cindy K Reiter
Sep 15, 2018·Frontiers in Molecular Neuroscience·Androniki RaftogianniValery Grinevich
Aug 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Aleksandra Suszka-ŚwitekAndrzej Jankowski
Jan 5, 2013·The Journal of Biological Chemistry·Denuja KarunakaranLeonard Kritharides
Jul 2, 2003·Brain Research Bulletin·Quanshun ZhangAmarendra M Kumar
May 11, 2010·Frontiers in Neuroendocrinology·Stuart P BlissMark S Roberson

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