Modulating vaccine responses with dendritic cells and Toll-like receptors

Immunological Reviews
Bali Pulendran

Abstract

The immune system is ignorant or even unresponsive to most foreign proteins that are injected in a soluble, deaggregated form, but when injected together with an immune-stimulating agent (i.e. an adjuvant, such as CpG-rich DNA), these foreign proteins can generate robust immunity and long-lived memory to the antigen. In fact, the nature of the adjuvant is what determines the particular type of immune response that follows, which may be biased towards cytotoxic T-cell responses, antibody responses, particular classes of T-helper responses, or antibody isotypes. Clearly, the ability of a vaccine to skew the response toward a particular type is of paramount importance, because different pathogens require distinct types of protective immunities. Therefore, the quest to manipulate the immune system to generate optimally effective immunity against different pathogens can justifiably be considered the 'grand challenge' of modern immunology. Central to this issue is a rare but widely distributed network of cells known as dendritic cells (DCs). DCs, which have been called 'Nature's adjuvants,' express pathogen recognition receptors, such as the Toll-like receptors (TLRs) and C-type lectins, which enable them to sense and respond to micr...Continue Reading

References

Aug 1, 1994·International Immunology·C CauxJ Banchereau
Aug 1, 1995·Immunology Today·A Kelso
Apr 1, 1996·The Journal of Experimental Medicine·G Süss, K Shortman
Oct 1, 1996·The Journal of Experimental Medicine·T De SmedtM Moser
Oct 31, 1996·Nature·A K AbbasA Sher
Sep 1, 1996·The Journal of Experimental Medicine·C C BleulT A Springer
Dec 8, 1998·The Journal of Experimental Medicine·B PulendranC R Maliszewski
Feb 2, 1999·The Journal of Experimental Medicine·R Maldonado-LópezM Moser
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Jun 22, 1999·The Journal of Experimental Medicine·T OhtekiS Koyasu
Aug 6, 1999·Immunity·T KawaiS Akira
Feb 9, 2000·The Journal of Experimental Medicine·R M SteinmanK Inaba
Mar 17, 2000·Immunological Reviews·R Medzhitov, C Janeway
Feb 7, 2001·Journal of Virology·D R DrakeA E Lukacher
Jun 3, 2000·Annual Review of Immunology·K M MurphyT L Murphy
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M WhelanK P Rigley

❮ Previous
Next ❯

Citations

Feb 14, 2009·Molecules and Cells·Sang-Moo Kang, Richard W Compans
Mar 3, 2007·Digestive Diseases and Sciences·Gary L DavisGyongyi Szabo
Jun 16, 2005·Current Opinion in Immunology·Bali Pulendran, Robert A Seder
Mar 26, 2008·Immunology and Cell Biology·Dawn M Jelley-GibbsSusan L Swain
Jun 21, 2006·Nature Immunology·Bali Pulendran
May 4, 2010·Nature Medicine·Tara M StruttSusan L Swain
Dec 8, 2004·Nature Medicine·Ronald N Germain
Apr 7, 2005·Nature Medicine·Achal PashineJeffrey B Ulmer
Apr 7, 2005·Nature Medicine·Harriet L Robinson, Rama Rao Amara
Jan 24, 2012·Nature Reviews. Immunology·Susan L SwainTara M Strutt
Mar 1, 2006·The Journal of Experimental Medicine·Silvia B BoscardinMichel C Nussenzweig
Mar 1, 2006·The Journal of Experimental Medicine·Christine TrumpfhellerRalph M Steinman
Feb 17, 2006·Cancer Biotherapy & Radiopharmaceuticals·Xueshu ZhangJim Xiang
Oct 13, 2006·Human Gene Therapy·Margaret A LiuGunilla B Karlsson Hedestam
Nov 19, 2013·Viral Immunology·Fu-Shi QuanSang-Moo Kang
Nov 20, 2004·Immunology and Cell Biology·Michael VajdyManmohan Singh
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Mihai G NeteaBart-Jan Kullberg
Jul 16, 2010·Clinical and Vaccine Immunology : CVI·I TamayoC Gamazo
Aug 23, 2005·Infection and Immunity·Ida RosenkrandsPeter Andersen
Apr 20, 2006·Infection and Immunity·Robert W KaminskiEdwin V Oaks
Mar 8, 2012·MBio·Maria del Pilar MartinRichard W Compans
Mar 18, 2005·Annual Review of Immunology·Louise J McHeyzer-Williams, Michael G McHeyzer-Williams
Jan 5, 2008·Annual Review of Immunology·Michael D Cahalan, Ian Parker
Mar 18, 2006·The Journal of Clinical Investigation·Stephanie DillonBali Pulendran
Jan 29, 2009·Journal of Translational Medicine·Philippe VeronCarole Masurier
Mar 3, 2005·PLoS Medicine·UNKNOWN Global HIV/AIDS Vaccine Enterprise
Mar 11, 2009·PloS One·Dimitrios G KoutsonanosIoanna Skountzou
Nov 7, 2007·PLoS Pathogens·Meimei ShanJohn P Moore
Aug 20, 2011·PLoS Pathogens·April Kaur RandhawaUNKNOWN South African Tuberculosis Vaccine Initiative Team

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.