Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

Viruses
Jonas D AlbarnazGeoffrey L Smith

Abstract

The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory.

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Citations

Oct 10, 2018·Expert Review of Vaccines·Natalie A ProwAndreas Suhrbier
Jan 1, 2019·Voprosy virusologii·S N Shchelkunov, G A Shchelkunova
Aug 17, 2019·Frontiers in Immunology·Evgeniya V ShmelevaBrian J Ferguson
Oct 30, 2020·Frontiers in Immunology·Misbah El-JesrCarlos Maluquer de Motes
Dec 3, 2020·Pathogens·Justyna Struzik, Lidia Szulc-Dąbrowska

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Methods Mentioned

BETA
acetylation
X-ray

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