PMID: 8985724Jan 1, 1996Paper

Modulation by alcohol and methadone of 2-deoxyglucose-stimulated pancreatic secretion in the rat

Fundamental & Clinical Pharmacology
C Nagain-DomaineC Vaille

Abstract

Alcohol intake is a major problem in drug addicts, and it is not clear whether the effects of alcohol and opiates are additive or potentiating. Vagally stimulated pancreatic secretion in rats is potently inhibited by opiates acting centrally at mu-receptors. In the present experiments, we determined the effects of methadone on 2-deoxyglucose (2DG)-stimulated pancreatic secretion in rats treated with acute (1.9 g/kg.3 h, intravenously) or chronic (1 or 3 month drinking) ethanol. In both acute and 1 month chronic alcoholic rats, methadone administered at its 50% inhibitory dose (ID50) reduced by about 50% 2DG-stimulated pancreatic secretion of sodium, bicarbonate and protein, and ethanol had only faint, nonsignificant inhibitory effects. In 3 month chronic alcoholic rats, similar results were obtained, but methadone inhibited 2DG-stimulated pancreatic secretion by 60 to 90% in these older rats. No significant interaction was found in any condition between ethanol and methadone, suggesting that they had only additive, but not potentiating effects in this method.

References

Apr 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R JoverJ V Castell
Apr 24, 1991·Brain Research. Developmental Brain Research·K AbnetS B Dunnett
Feb 11, 1986·European Journal of Pharmacology·J ChariotC Rozé
Jan 1, 1974·The International Journal of the Addictions·P W Haberman, M M Baden
Aug 7, 1981·JAMA : the Journal of the American Medical Association·M J EckardtK R Warren
Mar 1, 1981·Journal of Studies on Alcohol·J ChariotC Vaille
May 1, 1995·Journal of Studies on Alcohol·P W HabermanM C Dufour
Dec 15, 1994·American Journal of Medical Genetics·H W Gordon
Mar 1, 1994·Human & Experimental Toxicology·C Wu, J A Henry
Nov 1, 1993·Forensic Science International : Synergy·K Püschel

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